Saturday, May 18, 2024
Mitochondrial Health

#110 – Lew Cantley, Ph.D.: Most cancers metabolism, most cancers therapies, and the invention of PI3K

On this episode, Lew Cantley, Professor of most cancers biology and Director of the Sandra and Edward Meyer Most cancers Heart at Weill Cornell Medical School in NYC, walks us by his superb discovery of phosphoinositide 3-kinase (PI3K) and the implications for the care of sufferers with most cancers. He explains numerous combos of therapies being examined and used, together with the potential of pairing prescriptive dietary therapies to extend the efficacy of medicine like PI3K inhibitors. Lew additionally explains the metabolic nature of most cancers by the lens of his analysis into the connection between sugar consumption, insulin resistance, and tumor progress. Moreover, Lew gives some particulars about his thrilling new medical trial that’s simply now enrolling sufferers with stage four breast most cancers and endometrial most cancers.


We talk about:

  • Instructing science by the lens of discovery—a greater method to studying science [5:15];
  • The metabolic nature of most cancers, mitochondria, and a extra nuanced rationalization of the Warburg Impact [8:30];
  • The remark that satisfied Lew to cease consuming sugar [20:15];
  • The connection between weight problems, insulin resistance, and most cancers [25:30];
  • Sugar consumption and tumor progress—What did Lew’s 2019 paper discover? [32:00];
  • Pure sugar vs. HFCS, fruit vs. fruit juice, insulin response and most cancers progress [43:00];
  • Growing efficacy of PI3K inhibitors with ketogenic diets, SGLT2 inhibitors, and metformin [53:30];
  • Lew’s medical trial enrolling stage four breast most cancers and endometrial most cancers sufferers [1:07:30];
  • Pairing food plan with drug might be the way forward for most cancers therapy [1:09:30];
  • PI3K inhibitors available on the market, alpha vs. delta isoform, and the potential of pairing them with a meals prescription [1:16:15];
  • What questions will Lew be centered on within the subsequent chapter of his profession? [1:22:15];
  • Lew’s early work that finally led to the invention of PI3K [1:27:30];
  • Finding out the mechanism by which mitochondria make ATP [1:30:45];
  • How understanding the mechanism by which insulin drove glucose uptake right into a cell bought Lew nearer to discovering PI3K [1:38:15];
  • How Lew knew PI3K was necessary in driving progress of most cancers cells [1:55:00];
  • Lew’s unlikely remark of phosphorylation on the 3′ place of the inositol ring ensuing within the formation of phosphatidylinositol-3-phosphate [1:59:00]; and
  • Extra.


Instructing science by the lens of discovery—a greater method to studying science [5:15]

  • Peter proposes the concept science must be taught at a younger age by the lens of discovery
  • Presently, biology and different sciences are taught by rote memorization sadly
  • If we’re attempting to display for people who find themselves eager about science…what it’s important to be screening for is:

    • the method
    • the invention
    • the sport
    • the considering that went into the experiment

“Serendipity in science is totally essential that once you get a end result that’s sudden, you need to be laser centered on understanding on the biochemistry, on the chemical degree, why you bought the totally different outcomes then you definitely anticipated to get.”

  • Science is about one large thriller needing to be solved 
  • It’s about curiosity
  • Peter factors out that Lew’s profession has been much less about innate brilliance and extra about his need to observe an remark that had sudden outcomes

“If I get a end result that abruptly doesn’t make sense, to me that’s extra thrilling. It means there’s one thing extra difficult occurring than the only rationalization for what I’m seeing. . . if you happen to’ve damaged up a complete new area as a result of your easy rationalization doesn’t work and also you discovered why it didn’t work and what was mistaken, then that’s the place most breakthroughs come from.”


The metabolic nature of most cancers, mitochondria, and a extra nuanced rationalization of the Warburg Impact [8:30]

Round 2005…

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Lewis Cantley, Ph.D.

Meyer Director of the Sandra and Edward Meyer Most cancers Heart at Weill Cornell Medical School, Professor of Most cancers Biology in Medication

Lewis Cantley has made important advances in most cancers analysis, stemming from his discovery of the signaling pathway phosphoinositide 3-kinase (PI3K) in 1984. His pioneering analysis has resulted in revolutionary therapies for most cancers, diabetes and autoimmune illnesses. The creator of over 400 unique papers and greater than 50 e-book chapters and assessment articles, Dr. Cantley is a fellow of the American Academy of Arts and Sciences and a member of the Nationwide Academy of Sciences. He graduated summa cum laude with a B.S. in chemistry from West Virginia Wesleyan School (1971) and obtained a Ph.D. in biophysical chemistry from Cornell College (1975). He carried out postdoctoral analysis at Harvard College, the place he was appointed assistant professor of biochemistry and molecular biology in 1978. He turned a professor of physiology at Tufts College in 1985, however returned to Harvard Medical College as professor of cell biology in 1992. He turned chief of Harvard’s new Division of Sign Transduction, and a founding member of its Division of Programs Biology in 2002. In 2007, he was appointed director of the Beth Israel Deaconess Most cancers Heart. He joined the school of Weill Cornell Medical School and NewYork-Presbyterian Hospital in 2012.

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