Sunday, May 16, 2021
Mitochondrial Health

D loop replication

This DNA replication explains about the D loop replication process.
Download the study materials here-
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set-
Shomu’s Biology assignment services – -help
Join Online coaching for CSIR NET exam –

We are social. Find us on different sites here-
Our Website –
Facebook page-
Twitter –
Google plus-
LinkedIn –
Thank you for watching

D-loop replication is a process by which chloroplasts and mitochondria replicate their genetic material. An important component of understanding D-loop replication is that many chloroplasts and mitochondria have a single circular chromosome like bacteria instead of the linear chromosomes found in eukaryotes. However, many cloroplasts and mitochondria have a linear chromosome, and D-loop replication is not important in these organelles.

In many organisms, one strand of DNA in the plastid comprises heavier nucleotides (relatively more purines: adenine and guanine). This strand is called the H (heavy) strand. The L (light) strand comprises lighter nucleotides (pyrimidines: thymine and cytosine). Replication begins with replication of the heavy strand starting at the D-loop (also known as the control region). An origin of replication opens, and the heavy strand is replicated in one direction. After heavy strand replication has continued for some time, a new light strand is also synthesized, through the opening of another origin of replication. When diagramed, the resulting structure looks like the letter D.

The D-loop region is important for phylogeographic studies. Because the region does not code for any genes, it is free to vary with only a few selective limitations on size and heavy/light strand factors. The mutation rate is among the fastest of anywhere in either the nuclear or mitochondrial genomes in animals. Mutations in the D-loop can effectively track recent and rapid evolutionary changes such as within species and among very closely related species. Source of the article published in description is Wikipedia. I am sharing their material. © by original content developers of Wikipedia.


Similar Posts

25 thoughts on “D loop replication
  1. Thanx so much! It was pretty much clear. There's a confusion between L and H strands. The inner one must be L strand and the outer one H strand, with synthesis of H strand followed by that of L strand. I'm new to this so i could be wrong, though. Thanks, again.:>

  2. it called D-loope replication, it stands for displacement replication, because when the leading strand starts replication it displace the other strand, forming a D shape 🙂

  3. The video was fascinating. I have one question: Why does mitochondrial DNA replicate by the D-loop model whereas the bacteria (resembling the ancestors of mitochondria) replicate by the ϴ model? Please answer this sir. I have been looking for this question for last one year.

Leave a Reply

Your email address will not be published. Required fields are marked *