Monday, October 26, 2020
Mitochondrial Health

Mitochondrial fission and fusion



Mitochondrial fission and fusion – lecture explains about the mitochondrial division by fission and fusion.
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In most multicellular organisms, the mtDNA is organized as a circular, covalently closed, double-stranded DNA. But in many unicellular (e.g. the ciliate Tetrahymena or the green alga Chlamydomonas reinhardtii) and in rare cases also in multicellular organisms (e.g. in some species of Cnidaria) the mtDNA is found as linearly organized DNA. Most of these linear mtDNAs possess telomerase independent telomeres (i.e. the ends of the linear DNA) with different modes of replication, which have made them interesting objects of research, as many of these unicellular organisms with linear mtDNA are known pathogens.[17]

For human mitochondrial DNA (and probably for that of metazoans in general), 100-10,000 separate copies of mtDNA are usually present per cell (egg and sperm cells are exceptions). In mammals, each double-stranded circular mtDNA molecule consists of 15,000-17,000[18] base pairs. The two strands of mtDNA are differentiated by their nucleotide content with the guanine rich strand referred to as the heavy strand, and the cytosine rich strand referred to as the light strand. The heavy strand encodes 28 genes, and the light strand encodes 9 genes for a total of 37 genes. Of the 37 genes, 13 are for proteins (polypeptides), 22 are for transfer RNA (tRNA) and two are for the small and large subunits of ribosomal RNA (rRNA). This pattern is also seen among most metazoans, although in some cases one or more of the 37 genes is absent and the mtDNA size range is greater. Even greater variation in mtDNA gene content and size exists among fungi and plants, although there appears to be a core subset of genes that are present in all eukaryotes (except for the few that have no mitochondria at all). Some plant species have enormous mtDNAs (as many as 2,500,000 base pairs per mtDNA molecule) but, surprisingly, even those huge mtDNAs contain the same number and kinds of genes as related plants with much smaller mtDNAs.

The genome of the mitochondrion of the cucumber (Cucumis sativus) consists of three circular chromosomes (lengths 1556, 84 and 45 kilobases), which are entirely or largely autonomous with regard to their replication.

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9 thoughts on “Mitochondrial fission and fusion
  1. Woah man. Good Job! A tip for you though, take your time to articulate your words. We have after all an abundance of time and this helps people identify your words much easily. Also this helps when you are nervous and provides time to make your sentence much more flowing.

  2. This is glorious, I been tryin to find out about "high intensity mitochondrial biogenesis" for a while now, and I think this has helped. You ever tried – Miyason Mitochondria Masker – (search on google ) ? Ive heard some amazing things about it and my m8 got amazing success with it.

  3. Many thanks, I've been looking for "mitochondrial biogenesis markers" for a while now, and I think this has helped. You ever tried – Miyason Mitochondria Masker – (just google it ) ? Ive heard some great things about it and my neighbour got great results with it.

  4. Mitochondrial fission has be shown to occur as a result of He-Ne laser irradiation. Probably that was the first evidence of mitochondrial fission. For deaths see.Absorption of monochromatic and narrow band radiation in the visible and near IR by both mitochondrial and non-mitochondrial photoacceptors results in photobiomodulation.
    Passarella S, Karu T.
    J Photochem Photobiol B. 2014 Nov;140:344-58. doi: 10.1016/j.jphotobiol.2014.07.021. Epub 2014 Aug 21. Review.

  5. Passarella S, Karu T.
    J Photochem Photobiol B. 2014 Nov;140:344-58. doi: 10.1016/j.jphotobiol.2014.07.021. Epub 2014 Aug 21. Review. In this review you can find probably the first evidence of mitochondrial fission

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