Friday, May 7, 2021
Mitochondrial Health

"What is Apoptosis?" The Apoptotic Pathways and the Caspase Cascade



This 3D medical animation explains the functioning of the extrinsic and intrinsic apoptotic pathways. We start off by taking a look at the important role apoptosis plays in growth and development as well as removing DNA damaged cells. Then we see how activation of the caspase cascade occurs in each external and internal signalling pathway. Lastly we get a glimpse of cancer cells and their ability to block apoptosis.

© Elvire Thouvenot-Nitzan, 2016
http://www.elvirethouvenot.com

This resource is shared under Attribution-NonCommercial-NoDerivatives Creative Commons license (CC-BY-NC-ND 4.0). You are free to copy and reuse this for non-commercial purposes but we ask that you acknowledge “Elvire Thouvenot-Nitzan, created in collaboration with University of Dundee” when doing so. If you remix or modify this material, you may not distribute the modified material.

Medical Animator
Elvire Thouvenot-Nitzan BSc, MSc
Centre for Anatomy and Human Identification, University of Dundee

Medical Advisor and Pathology Instructor
Richard Oparka MBChB, FRCPath
Department of Histopathology, University of Dundee School of Medicine

MSc Medical Art Advisor
Caroline Erolin BA(Hons), PGCert, MPhil
Centre for Anatomy and Human Identification, University of Dundee

Technical Advisor
Annie Campbell BSc, MSc
Technology & Innovation Learning Team, University of Dundee School of Medicine

Attributions:

This animation features the track “Enrichment” by Podington Bear. The track is licensed under CC BY-NC 3.0 and has been edited to fit the animated short.
freemusicarchive.org/music/Podington_Bear/Backbeat/Enrichment

The animation features sound effects from freesfx.co.uk.

source

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36 thoughts on “"What is Apoptosis?" The Apoptotic Pathways and the Caspase Cascade
  1. i usually don't like to comment in youtube videos but after watching this i think you deserve a thank you from my heart one of the best videos in medical field that i have ever seen

  2. I'm so happy, i never believe i will be this happy again in life, I was working as an air-hoster for 3years but early this year, i lost my job because of this deadly disease called Herpes virus (HSV), I never felt sick or have any symptom, till all workers were ask to bring their doctors report, that was how i got tested and i found out that am HSV positive that made me loose my job, because it was consider as an STD and is incurable disease, i explained to a friend of mine, who always said to me a problem share is a problem solved, that was how she directed me to Dr Abumere , that was how i contacted him and get the medication from this doctor and i got cured for real, for similar issues contact this herbal doctor via [email protected]gmail.com you can also WhatsApp/call +2349021975055…

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  4. I'm so happy, i never believe i will be this happy again in life, I was working as an air-hoster for 3years but early this year, i lost my job because of this deadly disease called Herpes virus (HSV), I never felt sick or have any symptom, till all workers were ask to bring their doctors report, that was how i got tested and i found out that am HSV positive that made me loose my job, because it was consider as an STD and is incurable disease, i explained to a friend of mine, who always said to me a problem share is a problem solved, that was how she directed me to Dr Abumere , that was how i contacted him and get the medication from this doctor and i got cured for real, for similar issues contact this herbal doctor via [email protected]gmail.com you can also WhatsApp/call +2349021975055…

  5. Great! Great! Great! I watch A LOT of medical and A&P videos. This was not just uniquely beautiful to watch (honestly, probably a first in the thousands of medical videos I've watched), but you also did a wonderful job of isolating key concepts and explaining them clearly. (One thought– You may want to explain how cancers promote their own survival by blocking apoptosis. I'm not sure everybody would infer that. But that is a very small criticism in light of your accomplishment.). Wonderful job, both educationally and artistically.

  6. The activation of the initiator procaspase-8 was a little incorrect. Procaspases become activated by each other so there should've been at least 2 procaspase-8s that bound to the FADD death effector domain and then cleaved each other to become activated 🙂

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