Saturday, October 31, 2020
Mitochondrial Health

Glutathione, Oxidative Stress and N-Acetylcysteine (NAC) in Psychiatric Disorders – Prof Berk

Professor Michael Berk is currently an NHMRC Senior Principal Research Fellow and is Alfred Deakin Chair of Psychiatry at Deakin University and Barwon Health, where he heads the IMPACT Strategic Research Centre. This video at the Psych Scene Symposium takes you through studies that have demonstrated that there is reduced glutathione in major psychiatric illness, i.e. Schizophrenia and Bipolar Disorder. Oxidative stress can alter redox status impacting on methionine synthase, gene transcription, and protein expression.
N-Acetylcysteine (NAC) has robust effects on neurogenesis and apoptosis, directly reverses mitochondrial dysfunction, potent anti-inflammatory effects, and indirect effects on dopamine and glutamate.

Take-home Points

• Glutathione, the brain’s primary antioxidant, is decreased in schizophrenia and increased by NAC.

• Altered epigenetic signaling through oxidative stress may explain the relationship between childhood stress and vulnerability to developing adult illnesses.

• C-reactive protein, interleukin-6, and TNF-[Symbol] are important immune markers.

Full article:


Similar Posts

26 thoughts on “Glutathione, Oxidative Stress and N-Acetylcysteine (NAC) in Psychiatric Disorders – Prof Berk
  1. I suffer from a series of neurological and psychiatric disorders. Nine years ago, by mistake I once took 600mg of acetylcysteine a day when I was sad and whether through the placebo effect of from it's pharmacological profile I noticed that was doing better after a while and when I googled it I noticed that it was researched for psychiatric disorders.
    Although my experience is anecdotal I genuinely believe that there might be some misunderstood or even unknown mechanism of action that could be used for patient with psychiatric disorders.

  2. I fought anxiety my whole life maybe even when i was 3-4 years old and i couldn't do anything about it and i didn't want to take medications. I tried every supplement (B vitamins, ashwagandha, vegetable powders, L-theanine, phenibut, chelators, keto, etc… i cant even name them all), but nothing worked.

    I recently started taking NAC and oh my god. I took 1000 mg first time. It started with an excited state feeling, like inner tremor but it wasn't unpleasant. It was like something was cleaning out of my system and i haven't felt it since then.

    After my first dose my anxiety is gone, i couldn't believe it, i never felt calm in my whole life. My muscle tenses are gone, chronic sinus congestion is better. Unfortunately i recently picked up an addiction (before NAC). After every dose of that addiction i feel great anxiety and depression but every time i take NAC it kills it and i feel calm again.
    Its saving my life.

  3. Meth, or ice, kills neurons in the brain, causing people to lack the skills to think clearly.

    ADD/ADHD medication is basically meth/ice.
    So basically, ADD/ADHD medication is about stopping children from being able to think clearly, which explains why many are bored at school, and fine when playing video games.

  4. What about the animal studies of the cardiotoxic effects of NAC? Also, there was a study showing an increase in liver toxicity when taken during or directly after drinking alcohol.

  5. And Vitamin D is important for glutathione production. Recent studies suggest proper glutathione levels really helps reduce the oxidative stresses that cause the more deadly COVID complications for people with comorbidities like hypertension.

  6. Is it true tha NAC can act as an chelator, washing out heavy metals from the tissue? This can be good, but also bad, since it will mobilize the heavy metals within the body.

Leave a Reply

Your email address will not be published. Required fields are marked *