Monday, May 17, 2021
Mitochondrial Health

ELECTRON TRANSPORT CHAIN ANIMATION – Biochemistry High-yield Usmle step 1



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ELECTRON TRANSPORT CHAIN ANIMATION – Biochemistry High-yield Usmle step 1

Electron transport: pumps protons into intermembrane space
————————————————————————————————–

Complex I
—————-
Receives electrons from NADH.
Transfers electrons to CoQ.
Inhibited by rotenone, amytal.

Complex II
—————–

Receives electrons from FADH2.
Transfers electrons to CoQ
Coenzyme Q
Also called ubiquinone, or CoQ.
Transfers electrons to complex III.

Complex III
——————-
Transfers electrons to cytochrome c.
Inhibited by antimycin A.
Cytochrome c
Transfers electrons to complex IV.

Complex IV
——————-
transfers its electrons to oxygen, forms water.
Inhibited by CN-

Oxidative phosphorylation: uses proton gradient to make ATP
—————————————————————————————————
Complex V, also called ATP Synthase.
Oxidative phosphorylation occurs here, turning ADP to ATP.
Uses the proton gradient generated by electron transport.
Inhibited by oligomycin.
2,4-DNP, aspirin, thermogenin increases membrane permeability. Causes proton gradient to leak through membrane rather than fuel ATP synthase.

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