Lesson on the malate-aspartate shuttle explaining the purpose and mechanism of the shuttle. The malate aspartate shuttle is important for transporting NADH, produced from glycolysis, into the mitochondria for ATP production from the electron transport chain. The mitochondrial inner membrane is impermeable to NADH, so the cell needs to “transport” the energy within the NADH in another form (malate). Malate is then transported into the mitochondria, where the “energy” stored within malate is reprocessed into NADH, and this NADH can then be processed in the electron transport chain.
Hey everyone. In this lesson you will be introduced to the malate aspartate shuttle, why we need the shuttle, what types of cells use this shuttle, and how this shuttle functions. You will also learn about how gluconeogenesis utilizes this shuttle to produce glucose.
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