Wednesday, October 28, 2020
Mitochondrial Health

Malate-Aspartate Shuttle

Lesson on the malate-aspartate shuttle explaining the purpose and mechanism of the shuttle. The malate aspartate shuttle is important for transporting NADH, produced from glycolysis, into the mitochondria for ATP production from the electron transport chain. The mitochondrial inner membrane is impermeable to NADH, so the cell needs to “transport” the energy within the NADH in another form (malate). Malate is then transported into the mitochondria, where the “energy” stored within malate is reprocessed into NADH, and this NADH can then be processed in the electron transport chain.

Hey everyone. In this lesson you will be introduced to the malate aspartate shuttle, why we need the shuttle, what types of cells use this shuttle, and how this shuttle functions. You will also learn about how gluconeogenesis utilizes this shuttle to produce glucose.

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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.


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10 thoughts on “Malate-Aspartate Shuttle
  1. in ur other video on gluconeogenesis u said that oxaloacetate can be formed only in the mitochondria. In THIS video, y did u start with oxaloacetate on the cytosol side? isn't it supposed to be produced or made in the mitochondria?

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