Tuesday, September 21, 2021
Mitochondrial Health

Mitochondria & Aging – FORD BREWER



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ABOUT DR. BREWER
Dr. Brewer started as an Emergency Doctor. After seeing too many preventable heart attacks, he went to Johns Hopkins to learn Preventive Medicine. While there, he went on the run the post-graduate training program (residency) in Preventive Medicine. From there, he made a career of practicing and managing preventive medicine and primary care clinics. His later role in this area was Chief Medical Officer for Premise, which has close to 1,000 primary care/prevention clinics. He was also the Chief Medical Officer for MDLIVE, the second largest telemedicine company. More recently, he founded PrevMed, a heart attack, and stroke prevention clinic.

At PrevMed, we focus on heart attack, stroke, and cognitive decline. We serve patients who have already experienced an event as well as those who have not developed a diagnosis or event. Dr. Brewer provides services via telemedicine or in person if you’re in the Lexington, KY area. We find a lot of undiagnosed Pre-Diabetes or Insulin Resistance. Treating unrecognized risk factors like Pre-Diabetes allows reduction of risk and prevention of disease.

If you are interested in becoming a patient, please visit our website: https://prevmedheartrisk.com/

ABOUT THIS VIDEO:
WARNING -this article is for science geeks. It covers a scientific review article in 2018 on the role of the mitochondria in aging. The Free Radical Theory was actually first published in 1957. It shows how oxidation provides the power of mitochondria. But the resulting Free Oxygen Radicals cause mtDNA damage and decreases in mitochondrial function and mitogenesis(building new mitochondria). More recent evidence demonstrates mitohormesis. That’s the fact that lower doses of poisons end up prolonging life by causing adaptive change in the mitochondria. Mitohormesis is still a work in progress.
But we know how to improve mitochondrial function. Exercise (HIIT) and calorie restriction/fasting.

https://www.mdpi.com/2073-4425/9/1/22/htm#B3-genes-09-00022

https://academic.oup.com/geronj/article-abstract/11/3/298/616585?redirectedFrom=fulltext

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423095/#R32

source

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37 thoughts on “Mitochondria & Aging – FORD BREWER
  1. I first heard about mitochondria in seventh-grade biology. "powerhouse of the cell". I do HITT, intermittent fasting, take nicotinamide riboside and berberine. Is there any way to measure how our mitochondria are doing?

  2. I saw a few years back on TV a presentation that showed 2 days a week of 20 min HIT was more beneficial than daily exercise. There are issues to be aware of though if you are on any sort of diet, or have some issues. Check your bloods first…like a FBC. I used to get sick not long after getting back into HIT. Now I am pretty sure that because of another unrelated issue I had low iron, low RBC and low Haematocrit, so intense exercise with a lack of sufficient iron/oxygen was likely made me get sick after a little while . If you are over 55 I would recommend checking your bloods before undertaking any exercise Regime. (and still trying to resolve my RBC, just ordered up a faecal M2 PK test)

  3. Hello Dr. i became interested after learning from the "Bulletproof Coffee" founder who has been addressing this suggesting you can train your body to create the most healthy and stress resistant mitochondria…Alex

  4. I have happily made it thus far, but I did pause a bit while watching. Some are short, some are long, some are more medium. Like physical training—you want to mix it up (the length of your videos). Thank you Dr FB. .

  5. Eating a borderline ketogenic diet, intermittent fasting, exercise (weights and HIIT) and cold exposure are turning my mitochondria into little blast furnaces. I was always fairly cold tolerant, but as an athlete was brainwashed into eating tons of pasta and carbs. Now I'm pretty much a human fat furnace and at 15% body fat look years younger than my chronological age. Dr. Ben Bickman has really good research on cellular energetics. Mitochondria LOVE FAT. I'm pretty sure that statins kill your mitochondria.

  6. I like your new format – the articles posted behind you, instead of holding them up to the camera. I used a similar technique when I did engineering teaching videos, but I used about 3/4 of the screen for the material, and 1/4 for me.

    I thought the article might be a little more difficult to read, from your description (for science geeks only), but, surprisingly, I've read or heard about a lot of the stuff in this article already. Which surprised me. I've seen quite a few technical articles that I couldn't get through the first paragraph without a medical dictionary (or google). This one was relatively easy to read (little more complex than a Tolkien novel).

    I think we've talked about Mitochondria a few times, and I think it's long been known (or believed) to be a strong indicator of life span, and also, that they're passed down maternally. My grandmother went to 92, so I figure that's at least how long I've got, if I don't complicate my life with high blood pressure and diabetes (last pre-workout glucose was 72!). That's after dropping all of my meds.

    Another odd thing – I also do intermittent fasting, and don't eat before my workouts, but if I check my BG after my workout, it's high – over 100. Then I heard someone explain that, during a hard workout, your body is busy converting ketones into glucose (if you're keto-adapted – most cyclists are not, which is why they have to make frequent stops to "carb-up"), but when you finish working out, your body will continue to convert, which causes a bit of a flood of glucose. When I checked my BG before my workout, and it was amazingly low.

    I think they've made a big list of aging factors, I believe consisted of about nine things. Several of those are listed in this article. I've heard of SIRT1 through SIRT7, as I recall, sirtuins being the keys that unlock various genes as we (and our cells) age. I suppose there are probably many more sirtuins that we don't yet know about.

    For making marks on your computer, I used a graphics tablet. A mouse just won't do it.

    The 50-y-o Aging article says it was published in 1956, making it 62 years old. But it's locked-up behind a paywall, so we can't get to it, unless we go to a university library or something. Or pay $40 for it.

    As for this "copper-zinc (CuZn) antioxidant superoxide dismutase (SOD)," I've never heard of it, and never heard of the need for Cu in my diet. My mom used to push "C, Zinc and Calcium," but never said a thing about Copper. Where do I get that from??? Now I'm checking my vitamins…. 0.5 mg.

    Thanks again for another great video.

  7. Dr Brewer,
    I'm trying to connect some dots, and have a few questions, if you have a few min.!
    I know of several alternative medicine folks who recommend drinking very diluted hydrogen peroxide, or 'ozone therapy'. Some of them talk about 'oxygenating your body'. I advised someone I know to not do these things, because hydrogen peroxide (and the others) are paradigmatic ROS. As a highly reactive molecule, ingesting (or otherwise administering) an ROS will just start to destroy cell membranes/kill cells in the lumen of your organs. More speculatively, I worried regular ROS administration acting as a non-specific/general antibiotic, potentially leading to a general decline in GI bacteria populations, and so providing opportunity for other, opportunistic bacteria. (Does this seem right?)
    Also curious if the result of that large 'vitamin e study' — in which large doses of Vit E were correlated with mortality — if that result was plausibly due to suppression of mitohormesis?
    Are the themes you point out here (mitochondria, ROS, disease) thought to suggest a major mechanism for the relation between nutrition/health? What I had in mind speculating: (1) nutritional factors: junk food that causes high mitochondrial flux, foods without antioxidants, constantly being in a postprandial state -> (2) excess, and not fully mitigated, ROS production in mitochondria -> (3) cellular damage, esp. in mitochondria -> (4a) disease/aging & (4b) inflammation as a response to / marker of cellular damage.

    Thanks for your videos! I hope to work in preventative medicine down the road, so I love your channel!

  8. Dr. Brewer, thanks for creating and sharing this. I’m 40 and am obsessed with longevity (and some athletics) and my research and instincts have led me to the following: fasting, plant-based diet, dark chocolate and teas, good sleep, lots of exercise, low stress, supplements: PQQ, fish and krill oil, acetyl l carnitine, ubiquinol, creatine, am experimenting with citrulline and beta alanine as well. Also Sinclair’s expensive NAD and pterostilbene combination. I’m going to continue to watch your videos and process your information. Thanks again!!

  9. Neurosurgeon Dr. Jack Kruse has written a lot about the Mitochondria. Dr. Doug Wallace is the world's leading expert on mitochondria. If you want to keep your mitochondria optimal, get out into the sun on a daily basis and lay out nude. Also, cold thermogensis is good too.

  10. Yes. Mitochondria Heath study is a must. I Read Dr. Thomas Seyfried's book " Cancer as a Metabolic Disease". Is an eye opener. So yes, this will be excellent information for you to share.

  11. I'm new to the channel and haven't posted before. Your reviews are really interesting. I think I'll stay around for a while. Thank you for taking the time to put this work on the Internet.

  12. Dr. Brewer, do you have any data on the “awesome foursome” for mitochondrial support: Q10, L- Carnitine, D- Ribose and Magnesium. What is your opinion on that? Please make some more videos on supplements for mitochondria. Thank you!!!❤️

  13. Hello Dr. Brewer! Awaiting Dave Asprey (Bulletproof Coffees’) book on Mitochondria where he looks at making them stronger and more efficient via diet, exercise, supplements, light, sound etc. Alex Katsanos

  14. Magnesium and NADH ( 😒👉 aside from ferrous 😳👎 ) can relieve many of the dopamine deficiency mechanisms attributed to Parkinson's and Alzheimer's disease patients. My RLS, horribly augmented by ropinirole "treatment," is now cured. 🤗

  15. Thanks, Doc Brewer. Very helpful. I'm almost 65 and have been doing all i can to keep what was, my great health until type 2 threw me a curv ball 10 years ago. I am succeeding with your help.

  16. Five stars sir! As always, so grateful for your professional and academic background, and for your personal approach to every topic you address.
    There perhaps should be warnings related to how NMN, NR products, in the relatively high dosages currently marketed, can easily deplete methyl donors if not strategically addressed.

  17. Also worth a gander here is Travis Christofferson's book, 'Tripping Over The Truth', a fine exposition of the 'metabolic theory of cancer', i.e. specifically implicating mitochondria and mitochondrial dysfunction.

  18. Just a further note: Prof. C. David Rollo et al (McMaster U., Hamilton, Ontario) have been doing some remarkable work (animal research) over a decade and a half employing a multi-supplement regime that has been shown to 1) completely abolish cognitive decline (in mice), 2) cut mitochondrial damage in half!, 3) significantly increase stem cell activity, 4) dramatically enhance radiation resistance etc.

  19. I think mitochondria should become a household word. Furthermore, understanding their importance and function and how to maintain it should be a requirement of all humans.

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