Thursday, September 16, 2021
Mitochondrial Health

The Science of Aging



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Lifespans have been slowing increasing as medical technology improves, but could they extended massively or even indefinitely? We will explore the science of aging and Strategies for Engineered Negligible Senescence, SENS, the field looking at how to improve geriatric medicine to extend our lives and possibly even makes us biologically immortal.

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Listen or Download the audio of this episode from Soundcloud: Episode’s Audio-only version:

Episode’s Narration-only version: https://soundcloud.com/isaac-arthur-148927746/the-science-of-aging-narration-only

Credits:
The Science of Aging
Episode 158, Season 4 E44

Writers:
Isaac Arthur

Editors:
Aubrey de Grey
Daniel McNamara
Darius Said
Gregory Leal https://www.gregschool.org/
Jerry Guern
Keith Blockus
Konstantin Sokerin
Mark Warburton
Micahel Kope
Micahel Rae

Producer:
Isaac Arthur

Cover Artist:
Jakub Grygier https://www.artstation.com/jakub_grygier

Graphics Team:
Jeremy Jozwik https://www.artstation.com/zeuxis_of_losdiajana
Sergio Botero https://www.artstation.com/sboterod?fref=gc

Narrator:
Isaac Arthur

Music:
Denny Schneidemesser, “Luminous Rays” https://soundcloud.com/denny-schneidemesser
Miguel Johnson, “So Many Stars” https://soundcloud.com/migueljohnsonmjmusic
Aerium, “Fifth Star of Aldebaran” https://www.youtube.com/channel/UCRnUJY3l5vIJFGsY3XvW4dQ
Stellardrone, “An Ocean of Galaxies” https://stellardrone.bandcamp.com

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41 thoughts on “The Science of Aging
  1. I think that (given how quickly science is advancing) immortality will become a reality within my lifetime. I hope to at least live to 10,000 using such technology (assuming I'm not horribly overestimating the advancement of science, that is). I can't think of a single reason why I wouldn't want that, after all.

  2. My one issue with life extention is if that is placed over life quality. Ie life support when there is no hope of having a good life after. I think if we approach it from the angle of relieving suffering, and that then leads to living longer, that's great! But I don't want to live longer if that means just suffering longer.

  3. I have been a cryonicist since 1998. People are actually more afraid of the tech working because they know what isolation is and fear that future more than its opportunities. Nobody thinks anything other than a culture, small or large, that values them (me), will be the ones that revive these patients. It is the 2nd worst thing that can happen to you when current science throws up its hands and moves on. I plan on never using my membership for other than a social group, thank you.

  4. mtDNA is just shorthand for mitochondrial DNA, you might as well just say that.

    I think that for me the resistance I have to the concept is that I don't think that it's realistic and don't want to get my hopes up. It's an immensely complex problem that essentially boils down to curing all possible diseases (more or less) and doing all of the work that evolution hasn't had any reason to do. I don't believe that we're likely to see serious life extension within my lifetime, it's possible of course. Predicting how technology will advance is more or less impossible. But let's just say that I'm not holding my breath for this one. So I'd rather focus on problems that we are actually likely to be able to fix, such as curing another type of cancer or curing rheumatoid arthritis than speculating about an issue that seems so far off it might as well be star lifting or building a Dyson sphere or light-speed travel.

    People have lived with the expectation that they're going to die someday in the not too distant future since the birth of consciousness. Introducing the hope that they might live forever… I mean that is the sort of stuff that religions are made of, literally. I don't think that you should get peoples hopes up when the probability that the issue will be solved within their lifetimes is minuscule. In my opinion we should focus on all of the little problems that we can actually solve, once we have solved all of the little problems the big problem will be solved.

  5. Everyone talking about being bored of living beyond 120, if you are less than 40 yrs then how do you feel if I suggest you start planning for a death after you hit 50 ? If you are beyond 50, are you bored of your life yet ? I'm saying this cuz around 50 was the max life any human ever lived in the hunter gatherer times. That was the "natural" age of death for humans before complex societies started forming. Strangely enough no one seems to get bored of life after reaching 50 now that most people can.

  6. "All medicine is life extension."

    Yes. Just over a year ago, I contracted a still unexplained illness that ripped the myelin off of my lumbar spine. I lost 95%+ of the feeling below my waist. After treatment and therapy, I have 80%+ back, with full recovery expected in time. Now, I work hard at exercise and activity, and I eat a very healthy diet. I feel great, look a decade younger than my age, and am happy. I think we can all choose to extend both the duration and quality of our lives, and I see no downside to trying.

  7. The resistance to the notion of anti-aging therapies probably stems from the belief in an afterlife. If you genuinely believe you'll be going to paradise when you die, extending life becomes less relevant. At least, that's always been my interpretation of why so many people are averse to the idea.

  8. Re: weird cynicism with regard to aging. Whenever discussing certain philosophical or scientific topics I often get that feeling that intellect extension should be high on humanity’s list to pursue too. I do not consider myself that intelligent but the sheer amount of sloppy communication and reasoning I see concerning previous topics often amazes and frustrates me.

  9. This is the most amazing channel ever created. Thank you, Isaac, for making these videos! You are doing a great service to humanity. I intend to implement your lessons.

  10. We don't know how humans would live the extra decades or centuries that science will offer them.
    Currently, the aging process is also accompanied by hormonal changes that reduce libido and also "drive" (creativity, seeking new things, adopting new ideas) when most people get older. As we reach 50 years old, most adults have slowed down, and this slowdown is obvious in their personality.
    If we extend human lifespan, then we also have to manipulate the whole psychological and hormonal aging process, unless we want to end up with people living 600 years, but thinking like young people for only the first 40 (and acting like elders for the remaining 660). This would lead to a very conservative and even stagnating society, where most people are grumpy and don't want to change whatever they have. Even if you look young, even if your cells are kept in a state of youth, there is an aging process that is subtler and more structural going on in the brain. Perhaps there are simple solutions involving hormons, but there is a risk that the solution might be much more complex, and preventing people from becoming "old minds in a young body" will prove to be the biggest challenge.

    ps: Personally, I'd be happy to live 1000 years at least. I'd go through times where I want to learn everything, and times where I just want to walk around and contemplate. I'm 46 years old and I still have an innovative mind, though I am fully aware that my energy has faded a bit, and that I might become cynical if I am not careful.

  11. One more reason to elevate octopi via life extension πŸ˜›

    I fear that life extension for everyone just isn't economically viable but I suppose if the most influential of us get to live longer that's a start.

  12. John Norman's counter Earth, planet Gor, has some anti-age treatment that extends human life up to potentially for ever. Well, postpone old age. Is the only example in fiction I can think of where that possibility is presented as something that is offered freely on the market, affordable by basically everybody. Usually population grow seems far too difficult to deal with. People must get old and die so we can have place for new people, would look like.

    Elves (people who as you know usually share their world with flying lizards of dozens of tons who breath fire, and also can make grenades snapping their fingers) 'must' have children almost never, and have centuries of childhood for each. The necessity usually seems to be inevitable when you try to write a consistent fictional world. I am not comfortable with the necessary Math to separate the naive bigotry from solid foundation in this debate, but as far as I can see the "long life means slow reproduction" feels like something hard to brake.

    I admit, the possibility of world don't became an hyperbolic terrible place day to night if everybody stop declining with age is a self-evident notion that escaped me totally until I met this channel. Humanity would not necessarily need to limit the endless longevity to a dozen thousand aristocrats of some sort, not since the beginning. And space is a big place, so maybe that is a false problem and will never pass that.

    Why does that feel as strange as it feels? The notion of humanoids that never age is as old as Mythology, there is no shortage of intelligent species like elves who either live hundreds of human generation or never die unless they are killed violently.

    Could be that we want that so much (freedom from degradation of old age) that we fear to consider the possibility of that, and be proven wrong?

  13. Hello Mr Arthur..!!! Great Video..!! Uplifting..!!! I think you should look at Hormone release according to circadian rhythms. As we age these hormones releases get less and less as we age.

  14. If a lab produce a medicine that can cure things like diabetes rather than manage the simptons for a very long time in the living consumer, it wouldn't be profitable. We will only have large production of drugs that revert deseases like diabetes when research become the goal, not the product. Aging will too be the same.

  15. This was an amazing story and deserves more views! I will share with all my friends and family. Curing aging is a noble goal and one of the most important challenges for our civilization. I can only imagine how exciting it would be to live in a future where our population is the trillions or beyond and we are spanning multiple solar systems and giant rotating space habitats. Your channel is my favorite of all on YouTube. Thank you!

  16. anyone ever think of just creating a superior Mitochondria, implanting it in an unfertilized egg after removing the flawed one, and letting nature take its course?

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