Thursday, October 29, 2020
Mitochondrial Health

Lethal Muscle Loss, CV Inflammation & Mitochondria: the Nature Article – FORD BREWER

Dr. Brewer started as an Emergency Doctor. After seeing too many preventable heart attacks, he went to Johns Hopkins to learn Preventive Medicine. While there, he went on the run the post-graduate training program (residency) in Preventive Medicine. From there, he made a career of practicing and managing preventive medicine and primary care clinics. His later role in this area was Chief Medical Officer for Premise, which has close to 1,000 primary care/prevention clinics. He was also the Chief Medical Officer for MDLIVE, the second largest telemedicine company. More recently, he founded PrevMed, a heart attack, and stroke prevention clinic.

At PrevMed, we focus on heart attack, stroke, and cognitive decline. We serve patients who have already experienced an event as well as those who have not developed a diagnosis or event. Dr. Brewer provides services via telemedicine or in person if you’re in the Lexington, KY area. We find a lot of undiagnosed Pre-Diabetes or Insulin Resistance. Treating unrecognized risk factors like Pre-Diabetes allows reduction of risk and prevention of disease.

If you are interested in becoming a patient, please visit our website:

Loss of muscle is lethal in older people. It begins to go way up in the mid 60s. There is increasing risk of of disability associated with falls. But this study in Nature magazine shows that the same risks for CV inflammation are also risks for muscle loss. The mechanism is not known. But it’s believed to be loss of blood supply due to TN-F, MPO, Lp-Pla2,…. In short – CV inflammation.

We have a course on CV inflammation. We’re providing video training on how to measure your own CV inflammation. The CDC has always said, “Know Your Numbers.” They were referring to cholesterol and bp. We think it’s even more important to know you’re own CV inflammation numbers.


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30 thoughts on “Lethal Muscle Loss, CV Inflammation & Mitochondria: the Nature Article – FORD BREWER
  1. Your wife is wrong. The mitochondrial video is the first Brewer video I shared with my brother. Mainly because it explains why high intensity training is important in second half of life. So much better than a mere reference to a conclusion that most experts use. It is implausible to expect anyone to stick to a strict regime, without understanding the science in detail.

  2. I've found that falling is associated (for me) with loss of strength in stabilizing muscles the non-major muscle groups …I now used kettlebells for HIIT for their promise of forcing the stabilizing muscles to strengthen as I do the repetitions.

  3. If hormone therapy increases bone density and such , what's the point of boniva and drugs like that? If the hormones are low anyway and that's the root cause of osteoporosis (assuming ) , why not just use hormones?

  4. Thanks for this awareness. Another channel that may be of interest is Greysteel. Dr. Sullivan, also a physician that began as an emergency room doc started a gym for older folks and gets remarkable results by increasing strength through weight training.

  5. Thank you very much for the information. I appreciate your explanation of the terminology. I was hoping you would, as soon as I saw CVRF (Cardio Vascular Risk Factor). It helps to follow the conversation when I don't have to make a mental translation of unused terminology in my everyday speech. Most people outside the construction industry would be lost if I was talking about what I did for 30 years as an Ironworker. Enjoy.

  6. Medicare supplements were covering gyms through the Silver Sneakers programs that allowed you to join a gym for free.. Now there are cutbacks…. false economy.

    I have a gym in the house with an elliptical trainer and a bench, yoga mat, leg weights, free weights. I have a community pool and a hill with an uphill walk of a mile. Then I can drive to the beach in about ten minutes. From there I can walk, run, hike, or swim. The key is to do it.

    I also got referrals to physical therapy for my shoulder, back, and knee. That can be great stretching and resistance training. Orthopedic injuries often cause an inability to exercise. That can prevent you from doing aerobic exercise and resistance exercise. But you can break that cycle with physical therapy and pool therapy and get back to HIIT. My photo is three years old. I am 71. Medicare with a supplement will often pay 100 percent of physical therapy and one-half of a gym

  7. All ideas about how I can do HIIT would be very appreciated. I am 68 and I swam, ran trails in the Santa Monica Mountains, and did second level yoga for all of my adult life until my health got in the way. I have a severely torn rotator cuff that is not repairable from one of the multiple falls. Severe erosive inflammatory osteoarthritis, my right knee is now bone on bone, hands are a mess as well as my lower back. I have had multiple falls with broken bones mostly due to balance issues. (Even after all that yoga)
    Moving = pain. I bought a rebounder with a balance bar, but I cannot figure out how to use it for HIIT with this body.
    I do intermittent fasting. My diet has always been clean, good fat, as organic as possible, no carbs never had processed food in my life. Grass-fed beef once a week. My weight is perfect but my muscles are dwindling. Any ideas out there????

  8. Some of this hits on the exact issue I have had regarding statins….their effect on muscles, and I believe the literature indicates statins not only negatively effect both (1) cell membrane stability (2) certain stains affect myocyte differentiation/development. I researched the statins and settled on 20 mg Pravastatin + ezitimine after trying lipitor. I also found pitavastatin very good, but still had some muscle pain as well as the cost factor – if it were generic I might take 1 mg or 2mg pitavastatin instead of pravastatin. After starting on pravastatin, I did find my mental clarity declined significantly and I also had a TIA ( I have had hypertension off and on since I was 13 [weight and stress related for sure]). I did some fairly extensive PubMed research and settled on Pravastain because it does not penetrate the cell wall nor did it seem to affect intra-cellular cholesterol production. It is also one of the one or two statins on the lowest rank of muscle related side effects. An issue I had was finding if statin use was shown to decrease muscle mass, and found my research lacking. I lift weights and have since I was in my early teens – I have asthma and real cardio is not appealing to me- but since taking the statins my weight lifting frequency has declined. Also the consistency of my abdominal fat , using the hand on belly with vigorous circular motions [ not exactly supported in the research as a valid method] seems to be yielding this test result – my belly fat used to be hard (like wacking a boar's side) but is slowly becoming softer and my jelly like.

  9. Because insulin resistance primarily occurs in the muscle tissue (secondarily in the liver), maintaining muscle mass is important for more than just preventing falls. I found that I had to make changes to my exercise routine in order to be able to sustain long-term exercise with less injury downtime. For HIIT I changed from a treadmill to an elliptical to be easier on my knees and fortunately came across the "Body by Science" concept that doesn't strain my ligaments/tendons as much as normal resistance training.

  10. doc, you know what, you got a viewer from China who's first language is not even English, your videos sounds like a TED speech and I really enjoy it. QUESTION: I know that muscle loss can be reversed by training in the gym. If muscle lose is reversed, can CVRF be reversed as well?

  11. If you back out to 30,000 feet it makes perfect sense. Insulin is one of our main anabolic hormones. Especially with testosterone and HGH decreasing so much with age, insulin becomes one of the body's biggest proponents for growth (or lack of degradation). The mitochondria – insulin relationship seems so important!

  12. I keep resisting doing the resistance training. I get my dog walking in every day but at the age of 67 I can only do 15 chin-ups in a set, which is far short of 80 I want to do at age 80. Oh well, I guess I have 13 years to build up to 80.

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