Thursday, March 23, 2023
Mitochondrial Health

Cutting-edge correlative microscopy reveals how apoptosis starts in the mitochondria

Using cutting-edge correlative microscopy methods, Wanda Kukulski’s group in the LMB’s Cell Biology Division, in collaboration with Richard Youle’s group at the National Institutes of Health in the US, have now shed light on the process by which large mitochondrial ruptures form in initiation of apoptosis.

This video shows a 3D model of a mitochondrion during apoptosis, reconstructed from an electron cryo-tomogram. Two ruptures can be seen in the outer membrane (dark blue), although white edges on the dark blue outer membrane are where more of the membrane cannot be seen as this is from a very thin slice through a cell. Cristae folding of the inner membrane can be seen in light blue. Bax clusters are shown in red. After the rotation of the image, the second visible rupture includes holes in both the outer and inner mitochondrial membranes.

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