Tuesday, October 20, 2020
Mitochondrial Health

Autophagy Fasting Benefits the Brain and Mitochondria



Autophagy, the subject of the 2016 Nobel Prize in Physiology and Medicine, is a metabolic that kicks after a period of fasting. During this, cells disassemble and remove their dysfunctional components. This process is incredibly nourishing to your body’s performance and cognitive functions. In congruence with this, influence is reduced and the longevity of mitochondria is promoted. I definitely feel this is a valuable topic to consider. Many talk about the benefits of fasting with regards to fat loss, but the even deeper benefits are to the brain, mitochondria, and metabolism. Through this, focus, energy, and longevity increase.

Best,
Nikhil

Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC329619/

Autophagy wins the 2016 Nobel Prize in Physiology or Medicine: Breakthroughs in baker’s yeast fuel advances in biomedical research
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240711/
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https://www.youtube.com/channel/UCAohrrjG-3gEp5QF1WlM9_w



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20 thoughts on “Autophagy Fasting Benefits the Brain and Mitochondria
  1. mitochondrial autophagy. fasting isn't recommended by doctors for patients with mitochondrial diseases or a genetic mutation in their mitochondrial DNA. there's many types of mitochondrial diseases. umdf.org/types/ However one option for mitochondrial disease treatments could be to induce mitochondrial autophagy in only the mutant mitochondria. Unfortunately, the triggers (the exact amount of ROS Reactive Oxdative Species, it's what causes cellular oxdative stress like when one's blood sugar is over 240/250 )to tag mitochondria for autophagy. a molecule (i think it was something like parkins-pink1, don't quote me on that.) mitochondrial autophagy aren't made by mutant mitochondrial DNA.
    there are two types of mitochondria autophagy. universal mitochondrial autophagy which happens with fasting. a certain molecule tags mitochondria based on ROS in the mitochondria. and there's also selective mitochondrial autophagy which was still being researched according to my doctor. there's a lot of information on autophagy on pubmed.gov the nih's medical knowledge pool. but discovering the exact molecule for inducing mitochondrial autophagy (autophagy means self eating. weird, ikr?). autophagy which is short for mitochondrial autphagy works by tagging damaged mitochondria with a certain molecule on receptors outside of the damaged mitochondria. except for universal mitochondrial autphagy which indiscriminately tags mitochondria inside the cell which i assume causes that diminishing effect.
    once a mitochondria is tagged for mitochondrial autphagy. its eveloped by a membrane and a libosome which breaks the damaged mitochondria down into amino acids. the amino acids are recycled into the cell to make make newer fixed and pikapika shiny mitochondria and other cellular organells. who wants a new golgi apparatus? *sorry, nerd humor, there.
    for mitochondrial disease patients discovering the exact molecule that tags mutant mitochondria and what triggers the tagging of the mutant mitochondria can be a matter of life and death.
    you wouldn't want to infuce too much mitochondrial autophagy at one time though it would cause death from lack of energy or ATP. you know that mitochondria are the powerhouse of the cell and that power is from when ATP/Adenosine TriPhosphate loses a phosphate. it creates kinetic energy (thus becoming ADP. After ADP uses a phosphate you get that lactic acid “feel the burn“ icky feels. ouch. but Arnold says that burning sensation feel like he is orgasming. He is so apha-male bad*ss. typically ADP are recycled with the citric acid cycle aka the Krebs cycle in beautifully complex dance. more nerd humor.)and electric energy due to the release of one electron. love those electrons pushing neurotransmitters across synapses. mitochondria also perform more than just making ATP. mitochondria control calcium signalling in the brain as well.
    my wife has tried IF. she lost 8 kilograms. i'm proud of my wife.

  2. This may sound extreme but the last card that I feel that completed my royal flush in life was taking enemas after a prolonged fast.

    Your colon likely harbors pounds of matter that don't pass through. As you know, the colon absorbs moisture. These clumps and blockages can sit for years acting as a toxin factories. As regular used up food passes by these the toxins, it is picked up and reabsorbed into the body. Many diseases can be linked to these types of build ups.

    You seem like one who enjoys learning. This is a mostly glossed over area of health but a hugely vital area when it comes to general wellbeing.

    Good luck and thanks for the content!

  3. Great video, The only problem I have with it is the representation of Epicureanism as being hedonistic and indulgent; as this was far from the case (not your fault, a lot people misunderstand his wisdoms because he was falsely portrayed by his contemporaries). In fact Epicurus shared a lot of views with the stoics, but instead of the normal philosophical focus on being righteous, he focused on what made people truly happy. He encouraged people to live simple lives, to not indulge in high pleasure activities like excessive/unhealthy eating, orgies, lustful thinking, desiring wealth, etc (ironically all the things people accused him of doing). And instead that we should live by the little pleasures, the sensation of being full from a simple meal, tending the land, being creative, spending time with friends. He believed that living simply, and deriving happiness from honest activities was the true source of happiness, and that indulgence was in fact the antidote.

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