This presentation uses illustrations to help explain how fatty acids are transported from the cytosol and into the matrix of mitochondria via the carnitine shuttle. It also describes the role of L-Carnitine and acts as a prelude to the metabolic breakdown of fatty acids known as as beta oxidation. This forms part of series of videos that can be seen on this channel dedicated to fat metabolism.
8 thoughts on “Carnitine Shuttle and Fatty Acid Transport Into Mitochondria”
Bless you! I've been struggling with this for days.
This video is awesome so far. I'm not even in school anymore – just really curious to learn more about this topic. I have a question though – what is the difference between Acyl Carnitine and Acetyl L-Carnitine (which I actually take as a dietary supplement)?
This is amazingly good. The first time I found anyone explain that the ATP balance isn't actually an ATP balance at all.
A few questions:
1. Is there an alternative standard biochemical energy balance notation that is actually accurate? eg PPB (phosphate-phosphate bonds)
2. What is the threshold for fatty-acid length to be transported at all and what is the threshold for fatty-acid length to never be transported, similarly for diffusion and other means of crossing into the matrix and being CoA'd – is it just a partitioning of the space of fatty-acids by length between transport and diffusion. Is there a good set of distributions describing the rates for the various lengths and how the membrane composition varies by historical fatty-acid exposure due to a different acid appearing in the space that the membrane is around than the one that was in the space outside the membrane?
3. What changes in the chemical and energy balance of this process as the distribution of fatty acids is varied?
What happens to the fatty acids if you don't have enough l carnitine to shuttle them? Will the fatty acids remain as fat and prevent you from losing fat?
Are kcalories the same as regular calories? Or is one kcalorie worth a certain amount of calories?
Fantastic video. Thank you so much!
Thank you for your wonderfully clear and beautiful presentations!