Monday, May 29, 2023
Mitochondrial Health

Minimum fasting length required for autophagy | Guido Kroemer

A key regulator of the process of autophagy is a drop in cellular levels of acetyl CoA, an end product of nutrient metabolism. As one would expect, fasting – the abstention from all nutrients – is a potent inducer of autophagy. This is especially true in mice, which begin to experience autophagy within a few days of fasting. However, critical metabolic differences between mice and humans make it difficult to extrapolate these findings to humans. In this clip, Dr. Guido Kroemer describes the current state of knowledge about the minimum amount of time required for fasting-induced autophagy in humans.

This clip was taken from the FoundMyFitness interview with Dr. Guido Kroemer found at

Original episode published on July 31, 2017 ⏳ #aging #autophagy #cancer 🧫

About FoundMyFitness: Rhonda Patrick has a Ph.D. in biomedical science from the University of Tennessee Health Science Center, and St. Jude Children’s Research Hospital. She also has a Bachelor’s of Science degree in biochemistry/chemistry from the University of California. She has done extensive research on aging, cancer, and nutrition.

It is Dr. Patrick’s goal to challenge the status quo and encourage the wider public to think about health and longevity using a proactive, preventative approach.

Learn more about Dr. Rhonda Patrick and her mission for FoundMyFitness at

About Guido Kroemer: Guido Kroemer, MD, PhD, is a professor at the Faculty of Medicine of the University of Paris Descartes. He serves in a leadership capacity at multiple research and medical institutes in Paris, including the Medical Research Council (INSERM), the Gustave Roussy Comprehensive Cancer Center, the Cordeliers Research Center, and the Hôpital Européen George Pompidou. He is also an adjunct professor at the Karolinska Institute, Stockholm, Sweden. Learn more about Guido Kroemer at


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20 thoughts on “Minimum fasting length required for autophagy | Guido Kroemer
  1. can i ask a question? i've heard that long term fasts are hard on your heart, and the body breaks down heart tissue which can lead to heart palpitations. Is this true? what do i need to do to have a safe long term fast?

  2. Hindus (jains and buddhists included) have been doing it for 1000s of years. All this fasting, meditation etc sciences you hear about have been mastered by Hindus long ago. So don't underestimate a Hindu vegetarian diet. Meat is bad for you and the environment. You should eat it only if you think you can control your intake to say once a week or once a month. Read more about Ekadashi (literally meaning 11th day from the waxing or waning moon) 36 hour zero intake waterless fasting. Also, without a spiritual practice, you're only focusing on the body and that's good but you can gain more with a spiritual outlook.

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  4. The body uses autophagy when on a calorie deficit. You get all the benefits of autophagy this way without the need to fast. It depends on your goals. Some cancers also spread quicker with autophagy.

    So, speak with an expert and don't get your nutrition advice from people with an agenda. Like this channel.

  5. Deffo feeling benefits at the 48 hour mark where l believe autophagy really ramps up as well as AGH production which presumably helps the immunity to re-set.My issue is with finding a balance between Ketosis and Autophagy and if or where one cancels the other.I'm good with my weight 10.5 stone at 5ft 9ins and am trying to address a trapezoid inflammatory problem with a meatless (omad) regime long adapted to.I didn't set out to go the Ketosis route but find myself in that state judging by the infamous 'keto-flu' i find myself in,so guess i'm in 'dirt-keto' territory lol.

    I find it bemusing hearing dr Bergs regular recommended 'grass-fed' meat and eggs protocols but not having the coin for this l just quit the antibiotics ridden corporate farmed stuff and stick with fish which i imagine doesn't by definition get the same 'infusion' treatment as red-meat ?,but generally i'm finding a fry pan of chopped red onion,ton of mushrooms,cherry tomatoes,spinach,garlic and 2 fried eggs ,served on a sesame bagel,sees me good for over 24 hours regularly.

    I wish there was a definitive,nuanced guide to measure the intersections of a diet like mine more geared to Autophagy and AGH rather than strictly Ketosis but hard to judge if i'm on a self cancelling regime by snacking on a cheese and pickle bagel for example between the OMAD.Don't want to kill myself to live,maybe 2 x 72's a year for an immune reset ? very hard to gauge…conflicting information being what it is ?

  6. Pranayam is the best way to increase circulation of scavenger cells
    The pelvic veins don’t have valves
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    Various methods of pranayam employ different muscles of respiration to churn the blood
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  7. Why doesnt she shut up and let him get a word in…….. jesus just shut up. The poor guy is so patient while she is crapping on about predictable/ repetitive NONSENSE. she is soooo sssooooo dumb

  8. I discover there is a cure for herpes virus immediately I completely Dr Madida herbal treatment I found out about on YouTube, the herbal medicine cured me completely.

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