Defective and aging mitochondria contribute to a wide range of diseases. Mitophagy, the selective degradation of dysfunctional mitochondria, helps ensure that the body’s cells are metabolically efficient. It occurs when mitochondria self-identify as dysfunctional, offering themselves for mitophagy. Mitophagy is tightly coupled with mitochondrial biogenesis, the process by which new mitochondria are produced. Failures in mitophagy are associated with several chronic diseases, including cardiovascular disease, kidney disease, and Alzheimer’s disease. Mitophagy also plays roles in metabolic adaptation and development. In this clip, Dr. Guido Kroemer describes mitophagy, a cellular signal for mitochondrial biogenesis and a key player in other physiological processes.
This clip was taken from the FoundMyFitness interview with Dr. Guido Kroemer found at https://www.youtube.com/watch?v=Gm626MgpveI
Original episode published on July 31, 2017 ⏳ #aging #autophagy #cancer 🧫
4 thoughts on “Mitophagy: a signal for mitochondrial biogenesis, metabolic adaptation, and cellular differentiation”
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Waiting for david sinclair podcast :l
I expect better from Dr Patrick on demystifying this fission vs fusion, than this little chimplet of material on this critical topic.