FOLLOW ON INSTAGRAM:- https://www.instagram.com/drgbhanuprakash/
Channel Memberships: https://www.youtube.com/channel/UCG5TBPANNSiKf1Dp-R5Dibg/join
Pyruvate dehydrogenase complex – steps, regulation, and inhibitors
Pyruvate dehydrogenase complex deficiency results in impaired conversion of pyruvate to acetyl-CoA, reduced production of citrate, and thus an impaired TCA cycle, leading to severe energy deficits (especially in the CNS). Long-term treatment includes a ketogenic diet (high fat, low carbohydrate, glucogenic amino acids, e.g. valine) and cofactor supplementation with thiamine and lipoic acid.
The five cofactors of the pyruvate dehydrogenase complex: Tender (Thiamine) Loving (lipoic acid) Care (CoA) For (FAD) Nancy (NAD+).
Arsenic inhibits lipoic acid, thereby preventing the production of acetyl-CoA and inhibiting the TCA cycle!
#pdhcomplex #pyruvatedehydrogenasecomplexmechanism #pyruvatedehydrogenase #usmlestep1 #usmle #mbbs #biochemistry #biochemistryanimatedvideos #animatedmedicalvideos #usmlestep1videos #usmlevideos #usmlebiochemlectures #pdhcomplexanimation #neetpgbiochemistry #biochemistryforneetpg #usmlebiochemistry #mbbsbiochemistry #biochemistryanimations
13 thoughts on “Pyruvate dehydrogenase complex ( Biochemistry Animations ) – Mechanism , Regulation and inhibitors”
Complete animated Medical biochemistry for MBBS , USMLE and FMGE aspirants … visit http://www.medvizz.com ( a product of proceum pvt ltd ) , Complete package of biochemistry includes , Videos , Lecture notes , Mcqs and cases for usmle step 1.
Good work please complete.
excellent sir..its very easy to understand by animation..even its can be easy to remember it😍😍
Great sir 👍
Thanks a lot!
Grt video….easy to understand nd can remember for long
i luv u dr prakash
you're a lifesaver