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Mitochondrial dysfunction is one of the Seven Deadly SENS, one of the root causes of the aging process. The powerhouses of our cells, over 90% of our energy is produced by our mitochondria. It can be activated by exercise, cold temperatures, and fasting, but like so many other things, levels decline over time – even if you’re doing everything right.
PGC1α is the master regulator of mitochondrial biogenesis – in other words, it facilitates the creation of new mitochondria. At the same time, it improves the function of existing mitochondria by upregulating an assortment of genes involved in energy production. This reduces the overall load of work, which makes for less damage from free radicals.
Not surprisingly, transgenic mice made to express PGC1α showed significantly less oxidative damage than the control group. This is a tremendous discovery, as curtailing oxidative damage is an enormous step towards getting aging under scientific control.