Ira Pastor, ideaXme exponential health ambassador, interviews Dr. Magomed Khaidakov, Assistant Research Professor, Department of Internal Medicine, University of Arkansas for the Medical Sciences. https://www.amazon.com/Pessimistic-Guide-Anti-aging-Research/dp/1527534359
Ira Pastor Comments
Today we are going to be talking about mitochondria, among many other longevity and anti-aging themed topics.
We’re also going to talk a little bit about the role of pessimism and realism when it comes to the human translation of certain technologies, and why it is important to limit “messianic thinking” as much as possible.
The mitochondria are double-membrane-bound organelles found in most eukaryotic organisms and are responsible for generating most of the cell’s supply of adenosine triphosphate (ATP), used as a source of chemical energy. Thus mitochondria is termed the “powerhouse of the cell.”
Damage and subsequent dysfunction in mitochondria is an important factor in a range of human diseases due to their influence in cell metabolism. Mitochondrial disorders often present themselves as neurological disorders, but can also manifest as myopathies, diabetes, multiple endocrinopathy, and a variety of other systemic disorders.
The mitochondrial genome represents the full genetic complement of a mitochondria and contains approximately 16,600 base pairs, encoding 37 genes, and the polypeptides it codes for are all subunits of enzyme complexes of the oxidative phosphorylation system.
Also, mitochondrial dysfunction can not only be driven based on damage to these genes, but also to mitochondrial genes in the nucleus, leading to many rare diseases such as Friedreich’s ataxia, hereditary spastic paraplegia, and Wilson’s disease.
Dr. Magomed Khaidakov
To discuss this, and many other topics, I am joined by Dr. Magomed Khaidakov, Assistant Research Professor, Department of Internal Medicine, University of Arkansas for the Medical Sciences.
Dr. Khaidakov obtained his Doctor of Medicine (MD) from 1st Medical Institute, Moscow, Russia, his PhD in Molecular Biology, from the University of Victoria (UVIC), British Columbia, Canada and for the last few decades his primary research interests have been the biology of aging and degenerative pathologies, as well as identification and correction of biological design flaws that limit mammalian lifespan.
He is also the author of the recently published book “Pessimistic Guide To Anti-Aging Research.”
We will today hear from Dr. Khaidakov:
About his background and an overview of the importance of mitochondria in both health and degenerative disease. An overview of his theories related to species-specific lifespans and the correlation with accumulation of large deletions in mitochondrial DNA. Other important areas of anti-aging research, and their limitations. A futuristic view of anti-aging technologies. Finally, his perspective on the longevity biotech community and places for pessimism and realism to have a role in critical thinking of novel approaches.
Credits: Ira Pastor interview video, text, and audio.
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If you liked this interview, be sure to check out ourinterview with Dr. Lorna Harries, Professor of Molecular Genetics at University of Exeter Medical School.
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