At Ending Age-Related Diseases 2019, Amutha Boominathan of SENS Research Foundation discussed her work with mitochondria. Beginning by explaining the roots of mitochondrial dysfunction and its effects, she went on to describe the differences between codons in the mitochondria and the nucleus, the concept of codon optimization, and the challenges and practices of migrating mitochondrial DNA to the nucleus, which is the goal of the MitoSENS project. Finally, she discussed the MitoMouse project, a mouse model that shows that mitochondrial proteins can be effectively expressed with nuclear DNA, a technique that may be used in the future as a therapy for mitochondrial dysfunction.
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