Wednesday, October 28, 2020
Mitochondrial Health

Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)?

COVID-19 Update 63 with critical care specialist Roger Seheult, MD.

Dr. Seheult explains the theory that seems most plausible to us here at That COVID-19 is primarily a disease of the endothelium (the single layer of cells that line blood and lymphatic vessels). This hypothesis helps explain the increase in cardiovascular complications from COVID-19: strokes, myocardial infarctions, thromboembolism (pulmonary embolism, DVTs, and other blood clots), as well as many critical patients who do not appear to have classic ARDS symptoms (and have relatively normal lung compliance etc. as observed by the research of Dr. Gattinoni in Italy and others). A deep understanding of this theory requires a review of some foundational biochemistry including the electron transport chain and ATP – the energy currency of the body.

Links referenced in this video:

Johns Hopkins –

Worldometer –

CDC and Lag Time –

American Journal of Physiology –

Some previous videos from this series (visit for the full series):
– Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)?
– Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress
– Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19?
– Coronavirus Pandemic Update 59: Dr. Seheult’s Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC)
– Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID-19 (V/Q vs Shunt vs Diffusion)
– Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces?
– Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses?
– Coronavirus Pandemic Update 55: How COVID-19 Infection Attacks The Immune System & Differs From HIV:
– Coronavirus Pandemic Update 54: COVID-19 Antibody vs. PCR Testing; When to Relax Social Distancing?:
– Coronavirus Pandemic Update 53: Anticoagulation; Can Mechanical Ventilation Make COVID 19 Worse?:
– Coronavirus Pandemic Update 52: Ivermectin Treatment; Does COVID-19 Attack Hemoglobin?:
– Coronavirus Pandemic Update 51: State by State Projections; Ultrasound to Diagnose COVID19 Pneumonia:
– Coronavirus Pandemic Update 50: Dip in Daily New Deaths; Research on Natural Killer Cells & COVID-19:
– Coronavirus Pandemic Update 49: New Data on COVID-19 vs Other Viral Infections (Ventilator Outcomes):
– Coronavirus Pandemic Update 48: Curve Flattening in California, PPE in the ICU, Medication Trials:
– How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment:

Many other videos on COVID-19 (coronavirus outbreak, coronavirus symptoms, influenza, coronavirus epidemic, corona virus updates, coronavirus vaccine, boosting the immune system, vitamin D, vitamin C, Zinc, Quercetin, NAC, n-acetyl cysteine, Insomnia, PPE, hydroxychloroquine, ultrasound to diagnose COVID-19, coronavirus New York, COVID-19 and the epithelium/blood vessels) and other medical topics (ECG Interpretation, strokes, thrombosis, pulmonary embolism, myocardial infarction, hypercoagulation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.) at

Speaker: Roger Seheult, MD
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.

MedCram provides videos to a variety of medical schools, education programs, and institutions (please contact us at [email protected] if you are interested)

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MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
#COVID19 #SARSCoV2 #Coronavirus


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40 thoughts on “Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)?
  1. I take a proton pump inhibitor – I never knew what it really did except to reduce stomach acid. Can you tell me please, just how dangerous is this drug? I've been on it for over 10 years. But i'm currently on 10mg every third day. I switched to a nutritional ketogenic diet 4 weeks ago and really trying to heal my gut microbiome. I am feeling so much better already.

  2. that was very good! I love science and I remember the energy cycle of the cell – I learned so much here. And, I think this is perhaps the root of why covid is so terrible for some people. It makes so much sense. Why did it take so long for me to find ? More people should hear this. But, I guess you have to like science!

  3. I am all for it. If we can't find a good medicine to treat this illness right now, it's best to find harm reduction alternatives to mitigate the complications. Little by little everything helps.

    Now if we are looking at things to reduce potential blood clotting what is your opinion of using vitamin E for it?

  4. Could upregulation of the ROS system in smokers (to deal with the toxins in cigarettes) be responsible for their significant under-representation amongst COVID-19 sufferers? …or severity of the disease (difficult to say whether they are less susceptible to C-19 or are asymptomatic)? …or is it nicotine (which has vasoconstrictive effects, so obviously interacts with the function of blood vessels)…both? Smokers would be more likely to have comorbidities also, making this relationship even less likely to be a result of chance.

  5. Hi, I saw you did a video on far UVC light. I was wondering what your thoughts were on "ultraviolet irradiation of blood" aka, "the cure that time forgot" (is it the same thing? Or something different?). Thanks!

  6. I looked up ultrastructural Electron Microscopy of Covid-19 Endothelial Cells interaction & found one paper but it will not down load one pdf reader and the other app. I have keeps going back to the top & will not load as well. It's really weird.
    Try it ! There may be some antibody flourescence microscopy of Covid-19 & endothelial interaction to show viruses without resolution & optical microscope pathology. Do they still use HRP as a bio-marker for microscopy another possible search.

  7. This is BABESIOSIS inserted.

    Not Kawasaki…misdiagnosed BABESIOSIS again.

    Please do the research. Wuhan lab was researching this RARE disease in BATS in 2018. They sequenced it.

    Not a coincidence

  8. Sorry, looks like a wrong theory. Although for some patients Covid-19 ends up in vasculitis, the event chain is started with hypoxia caused by viral/bacterial pneumonia. Hypoxia causes overproduction of erythropoietin, which causes erythropoiesis in REPOS cells in the kidneys and hepatocytes. Bone marrow starts pumping out erythrocytes, platelets acclimating patients to hypoxemia. Subsequently the extra RBM undergoes hemolysis, causing vasculitis with all the associated damage in different organs.

  9. That's because it not a COVID-19 virus.its a blood cloting bacteria problem.. Italians have drop you all in it by doing the right thing… and speaking out.. due to not being sheep like the rest of you.. and the W.H.O. is caught out too for lieing..

  10. Dr. Seheult, which ACEI/ARBs do you prefer in these patients? In another of your video, you showed that famotidine could inhibit Sars Cov-2 and telmisartan was also on that list.

  11. Whats todays Gravity on earth? We had a magnetic pole shift. That could cause blood clots. Change in surounding Gforces. And Corvid19 Combined factor in circulation. Inflamation can go away with Detox pills and drinks.

  12. Benhur Lee, MD, a professor of microbiology at the Icahn School of Medicine at Mount Sinai, says the difference between SARS and SARS-CoV-2 likely stems from an extra protein each of the viruses requires to activate and spread. Although both viruses dock onto cells through ACE2 receptors, another protein is needed to crack open the virus so its genetic material can get into the infected cell. The additional protein the original SARS virus requires is only present in lung tissue, but the protein for SARS-CoV-2 to activate is present in all cells, especially endothelial cells.
    “In SARS1, the protein that’s required to cleave it is likely present only in the lung environment, so that’s where it can replicate. To my knowledge, it doesn’t really go systemic,” Lee says. “[SARS-CoV-2] is cleaved by a protein called furin, and that’s a big danger because furin is present in all our cells, it’s ubiquitous.”

  13. Sorry, got lost way back in the beginning. Will save this for another day to try again to get the better picture. Sounds strong for the case you're presenting.

  14. Agreed – I work in a pharmaceutical co as a lawyer and I find the medically qualified professionals all very arrogant and patronising but you explain complex concepts so well than any reasonably intelligent person could understand – thank you for all your amazing work – fantastic
    Mark Richards

  15. What you are presenting in all of your lectures so far is the pathology that occurs when COVID-19 patients are not screened early. Do you know that, thanks to screening tests developed by Dr. Thomas Yadegar, ICU Director at Providence Cedars-Sinai Tarzana Medical Center in California, that it is now possible to PREDETERMINE who will develop chronic complications and stop them from advancing to chronic conditions, conditions contributing to mortality? Check it out.

  16. Ventilators are not designed to be a treat all, end all cure. Patients treatments have to be individualized because each patients immune system responds differently to COVID-19. People are DYING ON VENTILATORS because their immune systems are not treated with immunosuppressants to stop its destructive behavior. When immune systems are running wild, major whole body inflammation is also occuring and both cause havoc that can be deadly.You are way down in the weeds in all the minute chemical details rather that looking at why these chemical changes occur and what can be done EARLY to stop deaths. The bullseye to zero in on to cure COVID-19 SHOULD BE HOW TO TEST TO PREVENT CHRONIC CONDITIONS. There is actually a panel of clinical "markers" to predetermine chronic patients (in time to prevent their progression) that has been developed by Dr. Thomas Yadegar at Providence Cedars-Sinai Tarzana Medical Center in California. Yes, this approach is working to stop deaths and you should probably help spread the word, don't you think?

  17. Thank you Dr Seheult for explaining the biochemical background of the oxidative stress cascades. Your lectures helps a lot in my clinical pharmacy field – Much appreciate your remarkable teaching prowess.

  18. Just look after your endothelial lining protecting your cells from the penertration by the virus or most viruses in the respiratory tract.
    Its not rocket science. You can get zinc and manganese and copper to keep your endothelial lining strong.
    You can read it up but here it is on video…
    Check the 17 minute mark on the video for the building blocks of the endothelial lining

  19. Dr Seheult your presentation is Brilliant.
    Chantilly Enzyme SerraNatto for digesting micro clots and thrombocytes. Rutin for vascular and capillary integrity. Mitochondrial Activator for ATP along Nox Genesis for vascular dilation.
    Your opinion matters. Thank You.

  20. Professor Seheult is a rarely gifted physician: Brilliant, rigorous, gifted teacher and a doctor who sees through the complexity to identify and explain the essential pathophysiology.

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