Friday, January 22, 2021
Mitochondrial Health

The Biology of Aging



It is the greatest inevitability of life – aging. Have you ever wondered what happens within your body, that leads to its gradual decline in function and ultimately #aging? The longer we live, the more likely we are to develop age-related diseases; including cancer. In recent years, #science has taken big steps in understanding the biology of aging. Scientists have discovered nine biological hallmarks that contribute to the aging process. Here’s how it works. More videos coming soon. Please rate☝️, comment👇, and subscribe☝️ if you like them, so that I can make more! Please send through requests for topics to cover as well. What do you want to learn about? #scienceinmotion  

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Music thanks to:  

Music by Adam Vitovský
DOWNLOAD LINK: https://www.adamvitovsky.com/one-story
Creative Commons — Attribution 3.0 Unported — CC BY 3.0  

Images thanks to:  

Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License.  
Some images designed by Freepik/vectorpouch/pch.vector/vectorpocket . Available from: www.freepik.com
Some images adapted from BioRender. Created with BioRender.com. Available from: https://biorender.com/
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Some footage/images purchased from Storyblocks. Available from: https://www.storyblocks.com/

References:

Efeyan A, Comb WC, Sabatini DM. Nutrient-sensing mechanisms and pathways. Nature. 2015;517(7534):302-10.
López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194-217.
Hoeijmakers JHJ. DNA Damage, Aging, and Cancer. New England Journal of Medicine. 2009;361(15):1475-85.
Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature. 2009;461(7267):1071-8.
Pan MR, Li K, Lin SY, Hung WC. Connecting the Dots: From DNA Damage and Repair to Aging. Int J Mol Sci. 2016;17(5).
Yu M, Hazelton WD, Luebeck GE, Grady WM. Epigenetic Aging: More Than Just a Clock When It Comes to Cancer. Cancer Res. 2020;80(3):367-74.
Fane M, Weeraratna AT. How the ageing microenvironment influences tumour progression. Nat Rev Cancer. 2020;20(2):89-106.
Calcinotto A, Kohli J, Zagato E, Pellegrini L, Demaria M, Alimonti A. Cellular Senescence: Aging, Cancer, and Injury. Physiol Rev. 2019;99(2):1047-78.
Sadighi Akha AA. Aging and the immune system: An overview. J Immunol Methods. 2018;463:21-6.
Saretzki G. Telomeres, Telomerase and Ageing. Subcell Biochem. 2018;90:221-308.
Herrmann M, Pusceddu I, März W, Herrmann W. Telomere biology and age-related diseases. Clin Chem Lab Med. 2018;56(8):1210-22.
Whitehall JC, Greaves LC. Aberrant mitochondrial function in ageing and cancer. Biogerontology. 2020;21(4):445-59.
Colloca G, Di Capua B, Bellieni A, Fusco D, Ciciarello F, Tagliaferri L, et al. Biological and Functional Biomarkers of Aging: Definition, Characteristics, and How They Can Impact Everyday Cancer Treatment. Current Oncology Reports. 2020;22(11):115.
Laconi E, Marongiu F, DeGregori J. Cancer as a disease of old age: changing mutational and microenvironmental landscapes. British Journal of Cancer. 2020;122(7):943-52.
Guerville F, Barreto PdS, Ader I, Andrieu S, Casteilla L, Dray C, et al. Revisiting the Hallmarks of Aging to Identify Markers of Biological Age. The Journal of Prevention of Alzheimer’s Disease. 2019;7:56-64.

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