Friday, February 26, 2021
Mitochondrial Health

Mechanism-based Off-target Screening De-risks Clinical Development of Antiviral Nucleoside/tide…



Presented By: Joy Feng, PhD

Speaker Biography: Joy Feng is a Principal Scientist at Gilead Sciences, Inc. She has a Ph.D. degree in Medicinal Chemistry from the University of Florida. During her postdoc training at Dr. Karen Anderson’s lab at Yale, Joy developed her deep appreciation of mitochondria while studying drug-induced mitochondrial toxicity using an enzymatic approach.

Webinar: Mechanism-based Off-target Screening De-risks Clinical Development of Antiviral Nucleoside/tide Drugs

Webinar Abstract: Nucleoside/tide analogs have played a key role in the treatment of viral infections caused by DNA viruses such as herpes virus and hepatitis B virus, as well as RNA viruses such as human immunodeficiency virus (HIV), hepatitis C virus (HCV), influenza virus, and most recently the coronavirus SARS-CoV-2, the pathogen causing the COVID-19 pandemic.

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15 thoughts on “Mechanism-based Off-target Screening De-risks Clinical Development of Antiviral Nucleoside/tide…
  1. It's a miracle that I am alive today. I encountered HERPES SIMPLEX VIRUS (HSV1/2) for four (4) years, six (6) months and twelve (12) days with my calculations, before I met the great Dr muthuka . I am from los angeles California, united state of America and I was affected with herpes virus. Herpes is a viral infection caused by the Herpes simplex virus, marked by painful, watery blisters in the skin or mucous membrane or on the genitals. This was what I suffered for four years. I have visited CVS Pharmacy in CA for treatment but no improvement. I met DrMarvel online while I was searching for a herpes cure. I read a testimony about his work. I give a try that now becomes a testimony in my life. I contacted Dr Marvel E-mail: [email protected]gmail.com.

  2. Hey everyone , please pass this information to your love ones .. Herpes virus seem incurable at the very beginning because I thought all hope was lost and I will never get cured . I was given antiviral Herpevex Acyclovir 800mg , the doctor said it will kill the virus only slowing it a bit from spreading to other parts .. The Doctor made everything worst for me because they told me there was no cure to this infection , and gave me a cream which I applied at the affected area , I was on this for the past 4months no improvement . So there was a day I came across with a testimony from a friend , so i contacted this herbal doctor on getting his herbal remedy for this infection , which I paid for and received medicine after a week and some days with instruction on how to take medicine attacked . I take medicine for 2weeks before going to the hospital for a test … I can show to you now that I'm herpes free !. I fully believed there is a herbal cure for herpes now.I am also using this means to inform you out there to get yours as well ! .. you can contact Dr Marvel on his email([email protected])

  3. Some months ago I had sex with the third guy in my life whom i was about to marry and now I have herpes. I couldn’t believe it because he wasn’t a random guy, he’s the closet guy I’ve had as a boyfriend, but it has been a never ending nightmare since. I’ve always believed in GOD and have asked him for forgiveness which is ironic. I felt like killing myself with the taught of having a husband and family will be quite difficult and i felt like I’m not really in the room when people are talking. I didn’t know what to do and pretty much cry and pray every day to God for help and looking at my family with so much love and feeling that i have disappointed them even though they don’t know. Until I meant a doctor, who promised to help me cure my disease through herbs. At first i didn't believe him, but to my greatest surprise i was cured completely by herbal remedy, the medical doctor also verified that i was cured. Special thanks to DrMarvel Don't be discourage because he that did it for me will also do it for you and you can contact him through his email on: [email protected]gmail.com.

  4. Using herbal natural remedy was what got me tested negative to HSV 2 after been diagnosed for years.I have spend so much funds on medications like acyclovir (Zovirax), Famciclovir (Famvir), and Valacyclovir (Valtrex But it was all a waste of time and my symptoms got worse To me It is very bad what Big pharma are doing, why keep making humans suffer greatly just to get profits annually for medications that doesn't work.I'm glad that herbal remedies is gaining so much awareness and many people are getting off medications and activating their entire body system with natural herbal remedies and they are become holistically healed totally. Quickly contact Dr Marvel herbal home now email him directly on [email protected] .com

  5. Herpes can be treated and cured permanently but only few believe it. I was diagnosed of HSV few years ago, my doctor told me there is no permanent cure for the disease, i was given antiviral medication to reduce the outbreak of the virus, at the initial stage it was not so bad till it progressed to the end middle stage were i had difficulties going about my daily functions I was totally devastated till I saw a comment about Dr. marvel, who have used herbal medicines to cure virus like HERPES, HPV, ALS, when I contacted Dr.Marvel via email, after a few discussion, he prepared the medicine and ship it to me, when I received the herbal medicine, I took it according to his instructions, few weeks later I went to the hospital to have a blood test and the test came back negative, i was cured and free from this Virus… That is why I am sharing my testimony so that people can also contact him for help, via his email:­ [email protected]} .

  6. Good day every one I want to inform the public on how I get cured of Herpes by a Doctor called Apala . I visited different hospital but they gave me list of expensive drugs to treat the symptoms and never cured me. A closed friend of mine introduce me to a Herbal Doctor who cured her. I was scared to contact him but I found people testimony online testifying about his goodness. when I contacted him I asked him series of questions, I also ask him to show me his herbal certificate and license given to him by his Government he gave all the information I needed that gave me hope. He send a Herbal medicine to me that I took and it seriously worked for me. am now Herpes negative. God bless you for being a sincere and great men. Am so excited, you can contact him if you have any problem whats-app +2349150342282.or contact him on email([email protected]) And he can also cure the following diseases

    1) HERPES

    2) HPV

    3) HEPATITIS

    4) ALS

    5) BLOOD CANCER.

  7. The conclusion by medical doctors that herpes has no cure is certainly not true because I'm a living testimony of how Dr Akuza uses black seed extracts and other herbal materials to cure herpes virus. I was on herpes virus for more than 2 years, and consulted many doctors for treatment but all they administer is antiviral drugs which depresses me even more. On this blessed day i went to the river side to reflect and maybe commit suicide due to my predicament. While there was a lady noticing I was deep in thoughts and asked me what the trouble is and I told her my pains she offered to help because she has also benefited from Dr Akuza cure. Right there she sent a mail to (Dr Akuza) who replied and requested I send him information about myself. This conversation changed my story for good because in less than 3 weeks of using his herbal remedies which he sent to me through courier the virus was completely out of my body and this shocked my personal home doctors. One would have thought the solution to this demon called (herpes virus) would come from the world recognized scientists. Hey, if you are tired of antiviral drugs, heartbroken and in need of a solution contact him on: [email protected]gmail.com or watch strap +2348072437003 and be cured. you can follow him on Instagram @drakuza1…

  8. Dr Adewale on YouTube Herbal medicine is a good remedy for herpes simplex virus cure.Seriously, his Herbal Medication worked for me, am a free person now without any problem, my HERPES result came out negative…

  9. I can just imagine how things will change in 1 month if I continue using Dr Adewale on YouTube Herbal Medicine. Thank you! I will continue to tell people about you Dr Adewale for your wonderful help in curing my Herpes ll. God Bless you Dr Adewale so much i love you.

  10. I got tested of herpes early this year, I experienced dark urine and ribs pain so I went to the hospital for treatment and I was diagnosed of Herpes. The doctor gave me anti-retroviral drugs to slowdown the viral load which later worsens the ailment because the drugs weren’t effective and I was so scared because they say it has no cure, out of frustration I told my friend about it and luckily he told me he ones battled same problem in the past but he was saved by Dr. Okhiria. He gave me his contact and reached him and I became well and tested negative after the treatment. Here is his contact if you have such case. contact: Phone:+2348054699334, Email:([email protected]gmail.com )

    Whatsapp:+2348054699334

  11. After 4 weeks of using Dr Madida herbal medicine for my Cold sore and herpes virus, it was cured. That was the reason I decide to let everyone know  that Dr Madida herbal medicine worked for me in curing my herpes because it is YouTube platform that I met Dr Madida.

  12. I'm very
    excited to inform everyone
    that I'm completely cured from my
    HIV, recently. I have used
    Oregano oil, Coconut oil, Acyclovir,
    Valacyclovir, Famciclovir, and some
    other products and it's really help
    during my outbreaks but I totally
    got cured from my HIV, with a
    strong and active herbal medicine
    ordered from a powerful herbalist
    and it completely fought the virus
    from my nervous system and I was
    tested negative after 1 week of
    using the herbal medicine. I'm here
    to let y'all know that HIV, and
    other STD virus has a complete
    cure, I got rid of mine with the help
    of Dr Edes and his herbal exploit.
    He also cured my cousin of HERPES, 11
    months ago. Contact him via email:
    ([email protected]), Call/write
    him on WhatsApp
    (+2348034814875)

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