Thursday, September 16, 2021
Mitochondrial Health

Age-Associated Cellular Decline AACD– Discover Mitopure™ Urolithin A, Mitochondria & Muscle Function



When you start to notice a growing gap between the strength and stamina you expect and what you are actually feeling, it may be due in part to a natural process called Age-Associated Cellular Decline or AACD.

Deep inside your body, mitochondria, your cells’ engines of vitality that power cellular function are constantly renewed and kept healthy by a process called mitophagy. But as you age, this process can slow down, reducing the pool of healthy mitochondria left to power the cells in your muscles and vital organs.

Leading scientists have conducted extensive research on nutritional solutions that can promote mitophagy, and have identified a specialized cellular nutrient called Urolithin A, also known as Mitopure™ UA. Clinical studies have demonstrated that Mitopure™ UA penetrates deep within your cells where it helps activate mitophagy, to remove mitochondria that are no longer performing well. Mitochondrial health is important for muscle function as you age.

Daily supplementation with the cellular nutrient Mitopure™ UA promotes the renewal of mitochondria in muscle cells to help address one of the key drivers of Age-Associated Cellular Decline.

To learn more about Age-Associated Cellular Decline, please visit www.myAACD.org

MITOCHONDRIAL DYSFUNCTION: A KEY DRIVER OF AGE-ASSOCIATED CELLULAR DECLINE

The science on aging has now shown the pivotal role mitochondria play in healthy cellular function and identified this “powerhouse” of the cell as a central factor controlling how we age. A single cell can have hundreds or even thousands of mitochondria. Working inside individual cells throughout the body, mitochondria produce the life-sustaining energy powering everything we do daily, from moving to breathing to thinking.

An essential function of mitochondria is to convert nutrients from the food we eat and oxygen from the air we breathe into ATP (adenosine triphosphate) — what naturally fuels our cells day and night.2 Each cell needs a sufficient number of healthy and fully functioning mitochondria so it can work at full capacity to meet ever-changing energy demands.

Once known only as energy producers, scientific insight into complex mechanisms within the mitochondria have transformed aging research. Our understanding of the pivotal role mitochondria play in the health of our cells after middle age has grown significantly. And, this has focused our attention on mitochondrial dysfunction as a key driver of accelerated cellular aging and Age-Associated Cellular Decline (AACD).3

Mitochondria are found in greater numbers in tissues and organs where energy needs are the highest such as your muscles, heart, brain, liver and kidneys.4 This is also why these organs are at greater risk of dysfunction and disease in older age as mitochondrial function declines. This progressive deterioration can lead to a variety of dysfunction such as:7-9

• Lack of motivation
• Decline in daily energy levels
• Poor exercise tolerance
• Muscular cellular strength and stamina decline

Over time, a noticeable loss of muscle strength and function and other signs of accelerated aging may happen. If these declines in functioning are not controlled, conditions such as sarcopenia (muscle loss) or cognitive diseases may develop.

In order to maintain efficient cellular energy production and healthy functioning, mitochondria are equipped with quality control mechanisms.10 Natural processes called mitophagy (removal of damaged mitochondria) and mitochondrial biogenesis (growth and division to create new ones) help to protect the mitochondria and cell from dysfunction.11

However, these natural processes tend to decrease in older age and are weakened by oxidative stress and inflammation.12 As these quality control mechanisms become less and less effective, errors begin to slip through. Because of this, poorly functioning mitochondria are able to survive and accumulate. The result is mitochondrial dysfunction and AACD.

References:
1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779179/#!po=52.5000
2. https://www.ncbi.nlm.nih.gov/pubmed/31387448
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779179/
4. https://www.ncbi.nlm.nih.gov/books/NBK22436/
5. https://www.ncbi.nlm.nih.gov/pubmed/23887139
6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683958/
7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196243/
8. https://www.ncbi.nlm.nih.gov/pubmed/29867098
9. https://www.ncbi.nlm.nih.gov/pubmed/31086967
10. https://www.ncbi.nlm.nih.gov/pubmed/26589414
11. https://www.ncbi.nlm.nih.gov/pubmed/17014364?dopt=Abstract
12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935730/

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Mitopure™ is a trademark of Amazentis S.A.

Unless otherwise indicated, all trademarks are owned by société des produits Nestlé S.A. Vevey, Switzerland, or used with permission. ©2020 Nestlé.

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