Wednesday, July 6, 2022
Mitochondrial Health

Enhancing glucose metabolism via gluconeogenesis in a zebrafish model of Dravet syndrome

Banerji et al. identified a gluconeogenesis modulator, PK11195, a known mitochondrial translocator protein ligand, that normalized metabolic deficits and suppressed electrographic seizures in a preclinical zebrafish model of Dravet syndrome. This suggests a novel metabolism-based therapeutic avenue to treat catastrophic pediatric epilepsies such as Dravet syndrome arising from ion channel mutations.


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