Workshop “Frontiers in ion channels and nanopores: theory, experiments and simulation” (FICN2021) from 2-5 February 2021.
Michael Grabe presents “How mitochondrial uncouplers induce proton leak”.
I will discuss on going work in collaboration with Dr. Yuriy Kirchok’s lab attempting to understand the mechanism of action of common mitochondrial uncouplers. Using both simulation and electrophysiological recordings directly from mitochondria, we show that fatty acids and well-known chemical uncouplers primarily induce proton leak across the inner-mitochondrial membrane via membrane proteins – not by shuttling directly across the membrane. Implications for energy metabolism will be discussed.
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This workshop is part of a project that has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 803213).