Friday, August 19, 2022
Cold Thermogenesis

Breaking Down Brown Fat – Treatment for Obesity & Diabetes



Diabetes and obesity are two highly prevalent chronic illnesses within today’s society, projected to cause millions of fatalities annually – far more than what’s expected from COVID-19. This video will take you through an overview of these conditions, including a discussion of the pathology and symptoms, with a major focus on brown fat and its potential as a treatment option in the foreseeable future.

This video was made by McMaster Demystifying Medicine students Aniqa Chaudhry, Mohammad Farzbod, and Danial Aminaei.

Copyright McMaster University 2020

References
Al-Goblan, A. S., Al-Alfi, M. A., & Khan, M. Z. (2014). Mechanism linking diabetes mellitus and obesity. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 7, 587–591. https://doi.org/10.2147/DMSO.S67400
Diabetes. (n.d.). Retrieved October 30, 2020, from
https://www.who.int/news-room/fact-sheets/detail/diabetes
Hildebrand, S., Stümer, J., & Pfeifer, A. (2018). PVAT and its relation to brown, beige, and white adipose tissue in development and function. In Frontiers in Physiology. https://doi.org/10.3389/fphys.2018.00070
Kumar Khemka, V., & Banerjee, A. (2017). Metabolic risk factors in obesity and diabetes
mellitus: Implications in the pathogenesis and therapy. Integrative Obesity and Diabetes, 3(3). https://doi.org/10.15761/IOD.1000179
Ramachandran, A. (2014). Know the signs and symptoms of diabetes. The Indian Journal of
Medical Research, 140(5), 579–581.
Sacks, H., & Symonds, M. E. (2013). Anatomical Locations of Human Brown Adipose Tissue.
Diabetes, 62(6), 1783–1790. https://doi.org/10.2337/db12-1430
Wang, C. H., Lundh, M., Fu, A., Kriszt, R., Huang, T. L., Lynes, M. D., Leiria, L. O., Shamsi, F., Darcy, J., Greenwood, B. P., Narain, N. R., Tolstikov, V., Smith, K. L., Emanuelli, B., Chang, Y. T., Hagen, S., Danial, N. N., Kiebish, M. A., & Tseng, Y. H. (2020). CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice. Science Translational Medicine. https://doi.org/10.1126/scitranslmed.aaz8664

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5 thoughts on “Breaking Down Brown Fat – Treatment for Obesity & Diabetes
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