Wednesday, November 30, 2022
Mitochondrial Health

Caffeine! + Microbiome + SSRI Genomics & Zinc + Oxygen Deprivation + Imeglimin || BioNews #2

Today’s papers:

Van Nguyen, T., Chumnanpuen, P., Parunyakul, K., Srisuksai, K., & Fungfuang, W. A study of the aphrodisiac properties of Cordyceps militaris in streptozotocin-induced diabetic male rats.
Vial, G., Lamarche, F., Cottet‐Rousselle, C., Hallakou‐Bozec, S., Borel, A. L., & Fontaine, E. (2020). The mechanism by which imeglimin inhibits gluconeogenesis in rat liver cells. Endocrinology, Diabetes & Metabolism, e00211.
Papastergiou, J., Quilty, L. C., Li, W., Thiruchselvam, T., Jain, E., Gove, P., … & Pojskic, N. Pharmacogenomics guided versus standard antidepressant treatment in a community pharmacy setting: A randomized controlled trial. Clinical and Translational Science.
Donig, A., & Hautzinger, M. (2021). Zinc as an adjunct to antidepressant medication: a meta-analysis with subgroup analysis for different levels of treatment response to antidepressants. Nutritional Neuroscience, 1-11.
Arnold, B. M., Toosi, B. M., Caine, S., Mitchell, G. S., & Muir, G. D. (2021). Prolonged acute intermittent hypoxia improves forelimb reach-to-grasp function in a rat model of chronic cervical spinal cord injury. Experimental Neurology, 113672.
Lee, H. S., Kim, E. N., & Jeong, G. S. (2021). Aromadendrin Protects Neuronal Cells from Methamphetamine-Induced Neurotoxicity by Regulating Endoplasmic Reticulum Stress and PI3K/Akt/mTOR Signaling Pathway. International Journal of Molecular Sciences, 22(5), 2274.
Hosseini, S. D., Rahimi, M. R., & Abbaspoor, M. (2021). Chronic Caffeine Ingestion Down-Regulates Liver and Visceral Adipose Tissue Inflammatory Gene Expression in High-Fat Diet-Induced Obesity. Journal of Advances in Medical and Biomedical Research, 29(135), 1-1.
Szabo, H., Hernyes, A., Piroska, M., Ligeti, B., Fussy, P., Zoldi, L., … & Tarnoki, D. L. (2021). Association between Gut Microbial Diversity and Carotid Intima-Media Thickness. Medicina, 57(3), 195.

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22 thoughts on “Caffeine! + Microbiome + SSRI Genomics & Zinc + Oxygen Deprivation + Imeglimin || BioNews #2
  1. Haven’t finished watching this video yet but wanted to comment on how you handled yourself on the RX muscle video. Stuck to your guns and did not apologize for something you find odious and completely wrong. I’ve been watching your vids since before the podcasts and seeing that only increased my respect for you and your content.

  2. Your very interesting I was wondering if you knew any natural estrogen blocker it’s a long story why I can’t order anything from underground sources

  3. Leo! i found you from derek. you sound VERY similar to me by a lot. with stomach issues to ADHD. I used my friends dexadrine in Uni and it made me just feel normal like i could actually study i was writing an essay. Anyways can we talk somehow? i need to ask you a few questions… shall i message you on IG? or email perhaps



  4. Zinc is amazing. Unlike SSRI’s and fish oil, which make me feel calm in a passive sense, Zinc makes me feel calm and confident when interacting with people (relieves social anxiety) and the world more generally (executive function). Chris Masterjohn has had some interesting recent videos about zinc that seem to explain this — apparently zinc is responsible for allowing sex hormones to access cell DNA. Also, according to Chris, our body can only process a limited amount of zinc at once, so it’s best to dose 10 mg every 5 hours (I use lozenges). I strongly suspect that zinc deficiency may explain why a lot of bodybuilders have mood issues or sometimes feel like they need high dose TRT just to feel “normal.” Let’s keep in mind that muscle ties-up zinc, just as bone ties-up calcium. So maintaining supraphysiological amounts of muscle mass will for sure lower zinc in the bloodstream (which is what mood depends on).

  5. Just discovered you on MPMD brother. You, Derek and the other guy (sorry his name isn't coming to me) are freakin knowledge bombs that everyone should be watching. Thank you!

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