Tuesday, August 3, 2021
Mitochondrial Health

POD: Ketogenic Diet causes Heart Cell Death and Decreased Mitochondria



Study: https://www.nature.com/articles/s41392-020-00411-4

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VIDEO REQUESTS:
0:00 – Introduction
5:51 – Study Design
7:15 – Study Results
35:34 – Conclusions/Take Away

#ketogenicdiet #ketosis #hearthealth

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24 thoughts on “POD: Ketogenic Diet causes Heart Cell Death and Decreased Mitochondria
  1. CORRECTION: In the conclusion I mention that this is likely more applicable to keotacidosis, but after reflecting on the data a bit more, I don't feel that to be accurate of the data presented. This is just as likely for a regular ketosis state as it is for a ketoacidosis state, considering this is a direct test of the ketogenic diet and ketones, independent of ketoacidosis. However, I stand by my point that none of this should be taken as definitively applicable to humans until clinical trials are done (the human data in this study is good, but it is associative and incomplete).

  2. Alarming, I will have to watch this. I intermittent fast and try to stay on Carnivore/keto diets.
    Carb cycling a antidote ? Back to oatmeal ?

  3. Wow…
    Cell damage.
    More Silly new diet fads.
    Atikson diet fat meat to lose weight insane.
    Medditerain diet proven for decades the most healthy ignored by "pop psuedo Science" fads.

  4. Thanks Nic! I jumped to the conclusions for now and going to watch it in detail later.
    I would like to know your opinion on "combining fats + carbs" in the same meal. The concept being that because insulin is high when we consume carbs if there is fat around it will likely go to storage:
    https://www.youtube.com/watch?v=qmAVooBkKKU
    I am a bit skeptical about Thomas .. so I will be waiting for your perspective 🙂
    Thank you a lot!

  5. Interesting, in my family we have a blood clotting disorder that runs in the family. My grandmother and uncle both heavily ate high fat diets and ended up dying of heart attacks. I also was leary of the keto diet because i wondered how that could possibly be healthy. I function best with varied diet with vegetables, carbs, fat and protein and daily fasting.

  6. I've been on Atkins for 25 years and extreme keto (less than 10 grams of carbs per day) for 2 years. I regularly fast, which raises ketones measured by blood test. I'm 74 years old and have shown no abnormal signs of heart or arterial disease in CT scans and electrocardiograms. I am fat adapted, my source of energy is predominantly ketones. Should I hurry to purchase my burial plot?

  7. Ketoacidosis essentially comes not from insulin resistance but from insulin insufficiency and your cells are starving to death and this allows ketones to go up into levels they would never normally approach. If your t2 diabetes gets that bad you are going to need to take insulin even if your blood sugars are OK and this could be what is killing off some humans on keto diet because obviously on a nonketo diet your blood sugars would be going crazy and you would be forced to take insulin. I don't think keto diet is something 99% of the population should be doing, it leads to all kinds of pitfalls like eating low protein, eating a million calories of cheese and on and on. However it should be safe at least from this effect in anyone who is not an extreme t2 diabetic. In the study they actually injected the animals with ketones which is pretty ridiculous since in rodents the normal maximum ketone levels are much lower than in humans. It seems the diet itself would be fine even for the rats, so I would not even worry about it if you are on keto. But there is nothing magic about ketones

  8. In the mice study is it correct to say that all groups of mice were fed the same diet, but some groups got extra fatty acids through injections? If so, is this an accurate representation of a real keto diet?

  9. I had trouble knowing what to eat, I’m new and my main goal is to build muscle and what works for me the keto diet that I got from ketogenerator.online . I’ve been using it for a couple of months and It’s been working for me, I don’t know if it works to lose weight but It has the option to. And remember if something is worth it, it aint going to be easy! I hope it helps 🙂

  10. Could you make a video clarifying why ketosis itself is particularly sought after? Other videos of yours suggest ketosis doesn’t result in significantly more fat loss than calorie restricted diets. Rather, you suggest that it simply makes it easier to eat fewer calories overall. Why then is ketosis important? Why not simply eat fewer meals which are generally lower in calories but satiating? TL;DR what’s the big deal about ketosis?

  11. Great video, and I'd be interesting to see more on this subject. Obviously keto diets and intermittent fasting both cause ketone production and both are highly favoured at the moment because they can reduce other health conditions, so perhaps there has to be some trade off elsewhere? Thanks again.

  12. I guess what is a bit ambiguous for me is whether or not your suggesting that cell death is a bad thing? With heart disease being a leading cause of death, couldn't lack of cell death be part of the issue assuming that the majority of people are following the "normal" western diet? I thought that the regulation of mitochondrial biogenesis was a way to increase longevity?

  13. I know regular fasting is good, not really for ketosis sake, but for other reasons such as autophagy, mitophagy, stem cell regeneration, etc. It make sense that fasts should be few and far between and that the normal, regular diet should be one of a nutrient and fiber-rich profile which only a varied, whole-food, mostly plant-based diet could give.

  14. Great content as always. Well levelled in terms of detail.
    Regarding the increased apoptosis rate in heart cells – this is fascinating. Might that actually be playing a senolytic effect? I'm not clear whether that level of apoptosis increase would have some positive and some negative effects.
    Also conscious that "control" suggests that one condition is normal and one isn't, which is fine when adding chemicals such as BOHB but I suggest we should be cautious presuming a specific diet, calorie intake or eating pattern is a legitimate "control" as that is a perspective based on common nutrition availability. Isn't it?
    Thanks again.

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