Thursday, June 17, 2021
Mitochondrial Health

POD: Too Much Exercise Hurts Mitochondria and Blood Sugar Tolerance?



Study: https://www.sciencedirect.com/science/article/abs/pii/S1550413121001029

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0:00 – Introduction
10:00 – Study Design
12:34 – The Results
55:30 – Conclusion/Take Away

#mitochondria #bloodsugar #overtraining

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10 thoughts on “POD: Too Much Exercise Hurts Mitochondria and Blood Sugar Tolerance?
  1. This is a complex one. I went a little deeper than I usually allow myself, but hopefully the schematic I made helps you visualize what is going on. I put 3-4 days of work into this, so I hope you guys get some benefit from it. The next episode will be on its impact on mitochondrial dynamics (how they behave), as well as mitochondrial stress. Stay tuned.

  2. You get a similar effect with metformin, and I believe it is your body trying to reserve enough glucose and ketones for the brain itself during prolonged fat burning exercise. The muscle cells also will use ketones when doing light exercise but will stop using it completely after a point even though it is burning mostly fat. I don't think the mechanism is known but my guess is that these are just here to make sure the brain has enough fuel, and that while this will possibly mean bad news for athletic performance on low carb diet it probably doesn't mean much for actual health. On the contrary we know that exercise protocols like wingates seem to have more fat burning than anything else, which is great news for people whose exercise goal is fat burning.

  3. The name of the paper is "Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers"
    The damned paper is pay-walled.
    84 million people are insulin resistant. https://www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/prediabetes-insulin-resistance.
    46.2 percent of the US population is type II diabetic. https://www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-statistics-report.pdf
    Unless diabetics are considered to be "healthy", at least half of the US population isn't considered in this study.

    What was the diet of the subjects in this study. Were they vegans, carnivores, or something in between?
    The amount of exercise isn't quantified. Is extreme exercise running a marathon, or a walk around the block?
    What were the ages of the subjects — 15 to 75? Is age irrelevant? What was the physical condition of the subjects — marathon runners, swimmers, bikers, TV watchers?
    What was the size of the study population — 10, 100, 1000, etc.?
    Is this research only a curiosity, applying to some small or even tiny portion of the US population?
    “`Academic paywalls are often presented as a moral or financial issue. How can one justify profiting off unpaid labour while denying the public access to research frequently funded through taxpayer dollars? But paywalls also have broader political consequences. Whether or not an article is accessible affects more than just the author or reader. It affects anyone who could potentially benefit from scholarly insight, information or expertise – that is, everyone.
    The impact of the paywall is most significant in places where censorship and propaganda reign. When information is power, the paywall privileges the powerful. Dictatorships are the paywall’s unwitting beneficiary.“` https://www.aljazeera.com/opinions/2013/1/18/the-political-consequences-of-academic-paywalls/

  4. Nitty Gritty! Nitty Gritty!
    (My presumptions is: The people listening to hour long podcasts on mitochondrial function, want as deep of a dive as possible.
    Otherwise we'd be listening to more of the shorter than 3 minute video pop-sci channels. Not that pop-sci is bad…)
    I'M HERE TO LEARN MECHANISMS from someone distinguished in the field, not factoids.

  5. You said in the beginning healthy men and women…would the results be different if athletes like a boxers, runners or body builders were incorporated in with “normal healthy” people? Would the fact that their bodies are use to specific torture and diets for years effect the way their bodies react versus the average healthy person and I don’t remember if you stated how long the study was,would the body reaction change over time of constant treatment?

  6. This channel is a true blessing to nerds like myself. Your work here might be under appreciated because the mass just want short simple answers to everything, but I really can't express how much I appreciate what you do.

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