Presenter: Dr. Michael Rape’, HHMI Investigator
University of California, Berkley
Title: Ubiquitin-dependent control of development and disease
Ubiquitylation is essential for cell fate specification in all eukaryotes, and mutations in ubiquitylation enzymes are often the cause of severe disease. We have identified several ubiquitin-dependent signaling pathways that ensure robust development and are often mutated in disease. By studying the molecular mechanism of ubiquitylation, we have been able to push the new therapeutic modality of induced protein degradation. In this presentation, I will discuss new stress signaling pathways that shed light onto the precise control of cell fate specification and that might provide multiple entry points for new drug discovery.