Friday, June 18, 2021
Mitochondrial Health

Are There Foods That Can Increase NAD? (Part II)

Papers referenced in the video:

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence:

NAD and the aging process: Role in life, death and everything in between:

Flavonoids as inhibitors of human CD38:

Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome:

Characterization of Anthocyanins and Proanthocyanidins in Some Cultivars of Ribes, Aronia, and Sambucus and Their Antioxidant Capacity:

Flavonoid glycosides and antioxidant capacity of various blackberry, blueberry and red grape genotypes determined by high-performance liquid chromatography/mass spectrometry:

USDA Database for the Flavonoid Content of Selected Foods:

Large changes in NAD levels associated with CD38 expression during HL-60 cell differentiation:

Effect of genotype and environment on flavonoid concentration and profile of black sorghum grains (incorrectly indicated as Dykes et al. 2013):

Luteolinidin Protects the Post-ischemic Heart through CD38 Inhibition with Preservation of NAD(P)(H):


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30 thoughts on “Are There Foods That Can Increase NAD? (Part II)
  1. There is a sorgum festival in West Liberty Kentucky, from which I've acquired several bottles, but they tend to languish in the back of the pantry. Thank you for the new motivation to incorporate it into my diet.

  2. Thanks. Excellent and important information. If we eat a quality high fiber plant based diet, as you suggested before, we'll get quite a lot of these flavonoids plus lower gram negative bacteria and maintain gut barrier function which also lowers CD38. BTW, on a recent talk by Dr. James Kirkland, posted on the Healthy Aging at Tufts University youtube channel, he showed a list of substances which have senolytic activity. Among them were luteolin, quercetin, and fisetin, but they would be used episodically, maybe once a month for 2 or 3 days at fairly high doses to kill senescent cells.

  3. Thanks for vindicating my heavy sorghum intake. It's worth saying that sorghum has many varieties to the point it's more of a spectrum. The 'black' sorghum I have is normally called red sorghum, and the 'red' sorghum found online and in health food stores is more of a pink at best. The flour of black sorghum looks purple and is actually the one to have a strong purple-red colour when cooked. I think it may help to not pay attention to the names and use colour as an heuristic.
    It's also worth mentioning that sorghum (and no doubt the other foods) contain a mixture of similarly structured polyphenols, contibuting to the benefit but neglected by the measurement of any single compound.
    It wasn't that long ago a read a paper showing that low-tannin sorghum (the lighter stuff) has much higher concentrations of polyamines, so it's not all for naught if it is on the pale side!

  4. Your videos are awesome! I always enjoy them and proceed to go down rabbit holes/ searching for studies concerning, for instance, enhancing bio availability. Then I'm lost for an hour, lol.

  5. Every one of your videos is so impactful. I literally think I've made a change to my daily life every time I watched one of your videos recently. No other channel has had that kind of impact.

  6. One additional comment I'd like to offer is that it might be very interesting to see if there are any synergistic effects of these different molecules on cd38 concentrations. Do they all use the same mechanism to inhibit cd38 or can they be combined to yield non-linear advantages?

  7. You should post about how NAD increases in the blood is useless without upregulating ENAMPT, so it can be absorbed into tissue and muscle.

    Levels of H2S in the body don't just act as a mitochondrial anti oxidant, it also upregulates ENAMPT.

    If you want to utilize NAD you need H2S.

    P.S Beta-Lapachone for increasing NAD levels.

  8. Thanks for the video Michael! I was curious and I crossed all the database of the IC50 study and all the flavanoids per food to check other food sources that maybe could make it to the top10. They are really country specific like "Tasmanian peppers" or "Illawara plums". Let's see how we implement all those in our diet.

  9. A real breakthrough would be to understand, why CD38 is increasing. In general: Why do we age at all? There are lots of thing increasing or decreasing. But why do these things happen?

  10. Using your graph for Apigenin, it appears that about 50uM would be sufficient to minimize it. For Apigenin, there are 270g/M. So, 50uM is about 13mg (270 x 50 /1000=13). Does this mean that 13mg per day would be sufficient? If so the 50mg Apigenin supplement sold by Swanson would be more than enough to minimize CD38. Is that so?

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