Wednesday, December 1, 2021
Mitochondrial Health

How to WIN the fight Against AGING | Aubrey de Grey on Health Theory



This episode is sponsored by Thryve. Get 50% off your at home gut health test when you go to https://trythryve.com/impacttheory

Scientific break-throughs are happening all around you. As technology advances, biologists such as the Chief Science Officer of the SENS Research Foundation, Aubrey de Grey, is leading the way to pioneering tech that will allow you to choose how long you want to live. For years scientists have been trying to find a way to slow down the aging process, but Aubrey introduces the idea of repairing the damage that aging does on the body to theoretically restore the body’s biological age to maybe 30 years younger. If you are familiar with the obsession I’ve had with living forever, you already know how much this excites me.

SHOW NOTES:

Quality of Life | Aubrey on why a long life depends on the quality and being invested in choice [0:58]
Reverse Aging | Why damage repair could be easier than slowing aging & the push back met [4:40]
Indefinite Life | Aubrey on why the result of expected life for reversed aging could be indefinite [8:08]
Structure Repair | Landing on the idea of repairing structure to restore cellular level function [9:32]
Pushback | Aubrey on pushback among scientists about reverse aging in biology [11:17]
Body Damage | Aubrey on self-inflicted damage being reversed to same level 30 years prior [14:13]
Longevity Escape Velocity | Aubrey on his theory how to reverse biological age 30 years [16:26]
Types of Damage | 7 categories of damage that correspond to therapeutic methods of repair [21:18]
Stem Cell Therapy | Aubrey explains how stem cells could treat loss of cell problems [22:17]
Cancer Treatments | Aubrey gives category of damage due to too many cells [23:26]
Senescent Cells | Aubrey explains how these cells can promote cancer [26:53]
Mitochondrial Mutations | Aubrey explains problems at the molecular level inside cells [28:53]
Cellular Waste | Aubrey breaks down how cellular waste over years impacts old age [33:35]
Macular Degeneration | Aubrey explains specific enzymes that could prevent blindness [35:24]
Excretion | Aubrey explains diseases that could be resolved by breaking down waste [37:50]
Alzheimer’s | Breaking down amyloid as extracellular waste and modest benefit [39:22]
Advancing Therapies | Aubrey gives sobering guess how close effective therapies are [44:07]

QUOTES:

“I want to make sure that my choice about how long to live, and, of course, how high quality that life will be, is not progressively taken away from me by aging.” [2:24]

“Old age is something that evolution doesn’t care about at all. Evolution only cares about the propagation of genetic information.” [34:41]

“you’ve got to fix them all. You haven’t got to fix any of them perfectly. But you’ve got to fix them all pretty well.” [43:28]

“what excites me is typically the breakthroughs that would take me half an hour background to describe why it’s even important.” [46:16]

Guest Bio:
Dr. de Grey is the biomedical gerontologist who devised the SENS platform and established SENS Research Foundation to implement it. He received his BA in Computer Science and Ph.D. in Biology from the University of Cambridge in 1985 and 2000, respectively. Dr. de Grey is Editor-in-Chief of Rejuvenation Research, is a Fellow of both the Gerontological Society of America and the American Aging Association

Follow Aubrey De Grey:
Website: https://www.sens.org/
Twitter: https://twitter.com/aubreydegrey
LinkedIn: https://www.linkedin.com/in/aubrey-de-grey-24260b/

Dive Deeper On Related Episodes:
Reset Your Age with David Sinclair https://youtu.be/IEz1P4i1P7s
Lifestyle For Longevity with Kellyann Petrucci https://youtu.be/l9QO0JlnU8w
Secrets To Longevity https://youtu.be/Ulm01gzU8rU

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33 thoughts on “How to WIN the fight Against AGING | Aubrey de Grey on Health Theory
  1. Thank you Tom for asking him specifically about whether or not killing all cells that express telomerase is dangerous (At least that's an interpretation of what you said). I've been looking for that answer for a while now.

  2. I am absolutely stunned and impressed by how informed Tom Bilyeu is on this subject especially the kinds of question he is asking Dr Aubrey. Since sharing is caring we thank you so much Tom Bilyeu for sharing through Impact Theory.

  3. Like everything in life its a trade off. In this case, immortality v having a wizards beard your whole life . You choose! 🤳

  4. Tom it's to late for you… This thechnogy/knowlage not exists yet and/or if exists you are too old to use it…
    All we can do, I mean people with more then 25 years, is to improve life quality at order years.

  5. No, I wouldn’t want to live for ever, because heaven is incomparable in happiness compared with life on earth, which is sometimes hell on earth!

  6. How the heck did they ever even figure all this stuff out? That mitochondria have their own DNA and what it does etc.. And how the heck did they count them..

  7. Money is an issue that everyone has for a better and luxurious life, life was hard for me until I started crypto market with Mrs Nora and earning $20,000 per week.

  8. @ 8:05 Dr. Grey says… "scientists really do not want to share a platform with people who sound like they are not scientists, however smart they know that those people are" .
    So true. For me, the only real science is the only science that is Universal, which is MATH.

    The well-known popstar scientist Neil De Grasse Tyson said:
    "Some people know enough to THINK they are right, but not enough to KNOW they are wrong."

    Although the sentence is a bit illogical, it has victimized Dr. Tyson Neil himself. He knows Astrophysics enough to "think" the Universe is 15 billion years old and started with "a Big Bang", but he doesn't know Math enough to KNOW he is wrong, because the Universe has NEVER started with "a" Big Bang. Localized big bangs can happen as "flea farts" inside the "eternal in time/infinite in space" goddamn Universe.

    Thinking the Universe has begun with an "explosion" is similar to "thinking" the number infinite has started with an explosion of number ones, duh…

    IMHO Dr. Grey is a real scientist and I am all for extending as much as I can the life of the present physical body I am occupying and so far I am succeding.

  9. Regarding the 36m30s mark on Lysoclear / how basically the immune system is not active in the eyes.. and that a derivative of vitamin-a accumulates in the back of the eye and is responsible for age-related macular degeneration.. would that be the drusen that deposits under the retina? I've heard it said that vitamin-a (ex. I-Caps' zeaxanthin & lutein) help with the eyes, but doesn't that increase the risk of drusen / AMD? Interestingly, I've heard that in about 20 percent of those with dry AMD, will develop blood vessels under the retina (due to vascular endothelial growth factor (VEGF)) and cause fluid to leak into the eye, aka *WET AMD*.

  10. The idea that the human body is a "machine" shows a lack of understanding of the full picture … and the nearly infinite capacities of the human body when one does not limit one's idea of the body to a simple "machine."

  11. "We're fairly pleased with ourselves." …said every arrogant man who tried to mess with Mother Nature and thought he could do better. Disaster follows.

  12. I take nmn and AAKG + glycine and taurine to fix the gut, which now seems related to aging and NAD reduction. I also fast for 36+ hours at least once a week.
    Some of the many benefits of fasting and low carb diet on the immune system, blood pressure, blood sugar and anti-aging, all backed up by clinical data:
    Thymus stem cells are regenerated, which suppresses aging and renews the immune system.
    Fasting stimulates phagocytosis, the ingestion of bacteria and viruses by the immune system.
    Blood pressure is quickly and dramatically lowered, which is very important for a good outcome with the current pandemic.
    Weght loss from fasting only loses10% lean tissue and 90% fat compared to the typical 25% lean tissue and 75% fat lost when calorically restricting for long periods.
    Blood clotting is reduced and blood clots and arterial plague are reabsorbed into the body.
    Vitamin D plasma levels are increased, and vitamin D in turn increases autophagy!
    Blood sugar and insulin are lowered, allowing white blood cells to move more freely throughout the body and do their job. Ideal blood sugar is around 80. Some viruses activate glycolosis (the release of sugar in the body) and clinically it has been shown that decreasing glucose metabolism in the body weakens the influenza virus.

    The hormone Leptin is an immunomodulator that keeps the body from attacking itself and obesity causes leptin resistance. Fasting very quickly reduces leptin resistance and leptin levels and one day of fasting can cut your leptin levels in half and gets your immune system working properly again!

    When you move out of MTOR your body shuts down the building blocks of the cell which are used to produce organelles and proteins. This means the mechanisms needed by viruses to replicate are by and large unavailable when you are in a deeply fasted state.

    It stimulates the AMPK complex and activates autophagy. Autophagy (literally self eating) will cause cells to recycle foreign matter such as viruses and kill cancerous and senescent cells. AMPK does many helpful things in the body including activating the body's antioxidant defenses.

    Deep ketosis virtually eliminates chronic inflammation in the body. This can offset the life threatening symptoms of viral pneumonia which effectively kills you through inflammation. This also creates BHB ketones in your body, which also help your immune system and anti-oxidative system, especially in the brain. Ketones also provide an additional energy source during infection, which is critical when trying to fight off a bug. In fact you can have as much as three times the total energy available in your blood when you are in deep ketosis, or even more.

    It increases mitochondrial function and repairs mitichondrial DNA, leading to improved ATP production and oxygen efficiency and thereby making cells better able to fight off infection. Increased mitochondrial function also has the added benefit of increasing your metabolism and cancer prevention!

    Your body releases interferon which is also triggered by the body during viral attacks to shut down the replication ability of the surrounding cells and stop infections.

    After 72 hours or more fasted, your body actually recycles large numbers of immune bodies and creates new ones, rejuvenating your entire system.

    When you fast, this stimulates apoptosis in senescent or genetically damaged cells. This kills these cells off completely. Senescent cells are responsible for the effects of aging and are the root cause of the development of cancer. If it were possible to destroy them all it would completely stop aging and cancer. That is not possible but fasting can help limit these effects by killing off many of the affected cells and limiting the future effects of aging.

    Fasting also releases BDNF and NGF in the blood which stimulates new nerve and brain cell growth, helping a great deal with diseases like MS, peripheral neuropathy and Alzheimers.

    In fact, the biochemical precursor to BDNF is beta-hydroxybutyrate, which is the same ketone the body produces to nourish the brain while fasting.

    Dieters losing weight through intermittent fasting show greater reduction in waist size and increase in insulin sensitivity for the same weight lost and alternate day fasters were shown to lose fat while gaining muscle at the same time over a six month period.

    Fasting has been shown to increase bone marrow volume by 10% and levels of carnosine in the body in as little as a few weeks.

    Fasting also increases telomere length, negating some of the effects of aging at a cellular level.

    Eating one meal a day can bring most of these benefits to a lesser degree, and adding a few entire days off from eating per week will have even more effect especially when starting to feel poorly.

    Exogenous ketones can aid with fasting, making it easier in healthy people and allowing some people with specific issues to fast in spite of them without worrying as much about hypoglycemia.

    Children, pregnant or nursing women should not fast for periods longer than 16 hours. People with pancreatic tumors or hypoglycemia generally cannot fast at all. Type 1 diabetics can also fast but it is more complicated and should be approached with caution. Those with Addison's disease may also be unable to fast without liberal use of exogenous ketones, depending on severity. If you experience extreme symptoms of some kind, especially dizziness then simply break the fast and seek advice.

    Resources:
    https://www.ncbi.nlm.nih.gov/pubmed/23876457
    https://repository.upenn.edu/cgi/viewcontent.cgi?article=1537&context=edissertations
    https://www.cell.com/cell/fulltext/S0092-8674(19)30849-9
    https://www.ncbi.nlm.nih.gov/pubmed/25686106
    https://www.ncbi.nlm.nih.gov/pubmed/24905167
    https://www.ncbi.nlm.nih.gov/pubmed/10859646
    http://www.sciencedirect.com/science/article/pii/S0005272806000223
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413655/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815756/
    http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00224-7
    https://www.ncbi.nlm.nih.gov/gene/25712
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779438/
    https://www.ncbi.nlm.nih.gov/pubmed/10232622
    https://academic.oup.com/ajcn/article/81/1/69/4607679
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017674/
    https://www.sciencedirect.com/science/article/pii/S1931312809002832
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895342/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526871/
    https://www.nejm.org/doi/full/10.1056/NEJMc2001176
    https://pubmed.ncbi.nlm.nih.gov/23408502/
    https://pubmed.ncbi.nlm.nih.gov/27569118/
    https://pubmed.ncbi.nlm.nih.gov/21410865/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407435/
    https://www.arcjournals.org/pdfs/ijrsb/v3-i11/7.pdf
    https://www.amjmedsci.org/article/S0002-9629%2815%2900027-0/fulltext
    https://pubmed.ncbi.nlm.nih.gov/20921964/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141719/

    https://clinical.diabetesjournals.org/content/36/3/217
    https://europepmc.org/article/MED/22402737?javascript_support=no
    https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2265.2005.02288.x
    https://www.collective-evolution.com/2017/05/16/study-shows-how-fasting-for-3-days-can-regenerate-your-entire-immune-system/
    https://www.health.harvard.edu/heart-health/abundance-of-fructose-not-good-for-the-liver-heart
    https://holistickenko.com/vitamin-d-kidney-liver-disease/

    This list compiled over months of research by the user known as Pottenger's Human on youtube but feel free to copy and paste this anywhere you like, no accreditation needed!

  13. Thank you @Tom Bilyeu for a fascinating interview! The "pro-aging trance" is a new term for me that I'll be using in my talks. I'm investigating ways to activate one's own stem cells, thereby bypassing the risks, costs, dangers, ethics, etc of stem cell infusions/injections. Have you heard of using non-transdermal phototherapy patches to activate your own stem cells (via increasing GHK-cu peptide)? There are many studies to show the efficacy. Let me know if you want info. Happy to extend another friend's life. Onward!

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