Friday, June 18, 2021
Mitochondrial Health

EX-e: Ketones REDUCE Heart Mitochondria



Study, Notes, & Amendments: https://www.physionic.org/examine/ketogenic-diets-inhibit-mitochondrial-biogenesis-and-induce-cardiac-fibrosis

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#ketones #mitochondria #ketogenicdiet

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17 thoughts on “EX-e: Ketones REDUCE Heart Mitochondria
  1. What happens in a healthy person who eats and metabolizes a keto diet? Not sure how that would be measured, but mice, petri dishes and sick people don't seem like a good measure, but you did say you need more studies.

  2. Thanks for this video. Do you think I should stay away from keto as I have hypertrophic cardiomyopathy? This study is a worry.

  3. Ketones are more for fasting than something meant to happen all the time, and fasting is definitely healthy if you don't take it too far. On keto diet you are not going to get to 2.5 let alone 10.0 which is the start of ketoacidosis and normally won't even happen during fasting. So if they are genuinely trying to study keto diet then this is not a well designed study at all.

  4. Would the results be different if keto adapted and focusing on unrefined oils, omega 3 rich, nuts, seeds, avocado and olives plus lots of non starchy vegetables?
    I wonder if these negative effects you mention are for those who are not metabolically flexible.

  5. Please can you discuss the new research review finding that ketones increase metastatic cancer in particular palmitic acid. I always thought it was sugar, then there was research on animal protein increasing IGF1. Now what does one do?

  6. Since CoQ10 is known to protect cardiac mitochondria, it would be interesting to see if CoQ10 could counter the effects of ketones on the heart as proposed in this study. For now, I will supplement while fasting.

  7. @Physionic As far as I am concerned heart muscles do prefer ketones for energy. Would it make sense then that on a (strict) ketogenic diet less mitochondria are needed hence less mitochondria are found in the tissue?

  8. It would be nice to do a broader review, as other studies have shown exactly the opposite. For example, the first study below shows a positive effect of IV ketones in heart failure in humans. The other studies are in rats, but show a positive effect in skeletal muscle mitochondria:

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260463/

    https://pubmed.ncbi.nlm.nih.gov/32920139/

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069456/

    https://insulinresistance.org/index.php/jir/article/view/25/58

  9. A few people have suggested that mitochondria may be getting more efficient, if there are fewer – this is a great point and shows true critical thinking on your part, I really appreciate the thought process and its a scientific, logical way to think of the situation (well done, all!); however, the researchers did measures for mitochondrial activity and found a decrease in mitochondrial activity (by measure of an experiment called a "Seahorse assay"). Granted, this is an absolute measure, so really, it should be quantified in a relative sense per unit of mitochondrial content, but most likely (and this is an assumption on my part), we would at best see no increase in mitochondrial efficiency based on the data. Again, great thinking, everyone – I love it!

    I didn't present this data in the video, but it is in the study if you care to look at it (figure 3).

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