Monday, October 18, 2021
Mitochondrial Health

STRESS & LACK OF SLEEP Is Destroying Your Brain & CAUSING MIGRAINES! | Mark Hyman & Todd LePine

Migraines are a big problem for many people. These severe, nearly disabling headaches can occur anywhere from once a year to three to four times a week. They can last from hours to days. They are often associated with an aura, light sensitivity, nausea, vomiting, and severe throbbing pain on one or both sides of the head. And migraines can be caused by many different factors. This is where Functional Medicine comes in. Functional Medicine is medicine by cause; not by symptom. It helps us discover the underlying triggers of disease. And the root cause of your migraine may not be in your head at all. In fact, migraines can be caused by things ranging from food sensitivities and allergies to hormonal imbalances, vitamin deficiencies, and more.

In this episode, Dr. Hyman sits down with Dr. Todd LePine to discuss the Functional Medicine approach to ending migraines. They explore how to identify and eliminate what might be causing your migraines and share specific patient migraine cases they have treated.

Dr. LePine graduated from Dartmouth Medical School and is Board Certified in Internal Medicine, specializing in Integrative Functional Medicine. He is an Institute for Functional Medicine Certified Practitioner. Prior to joining The UltraWellness Center, he worked as a physician at Canyon Ranch in Lenox, MA, for 10 years. Dr. LePine’s focus at The UltraWellness Center is to help his patients achieve optimal health and vitality by restoring the natural balance to both the mind and the body. His areas of interest include optimal aging, bio-detoxification, functional gastrointestinal health, systemic inflammation, autoimmune disorders and the neurobiology of mood and cognitive disorders. Dr. LePine teaches around the world, and has given lectures to doctors and patients at American College for Advancement in Medicine (ACAM), Age Management Medicine Group (AMMG), the University of Miami Integrative Medicine Conference, The Kripalu Center in Lenox, MA, and is on the faculty for American Academy of Anti-Aging Medicine (A4M). Dr. LePine is the head of the Scientific Advisory Board for Designs for Health and a consultant for Diagnostic Solutions Laboratory. He enjoys skiing, kayaking, hiking, camping, and golfing in the beautiful Berkshires, and is a fitness enthusiast.

This episode is sponsored by Rupa Health and InsideTracker.

Rupa Health is a place for Functional Medicine practitioners to access more than 2,000 specialty lab tests from over 20 labs like DUTCH, Vibrant America, Genova, Great Plains, and more. You can check out a free live demo with a Q&A or create an account at

If you’re curious about getting your own health program dialed-in to your unique needs, check out InsideTracker. Right now they’re offering Doctor’s Farmacy listeners 25% off at


Similar Posts

19 thoughts on “STRESS & LACK OF SLEEP Is Destroying Your Brain & CAUSING MIGRAINES! | Mark Hyman & Todd LePine
  1. I don't eat a lot. I basically eat because I have to go to work. So I eat two eggs two bacon and coffee. So when I get to work I'm not hungry and wait until my break. Then at work I have cheese and pepperoni . Dinner with family . Should I just skip breakfast and see what happens? I'm not hungry in the A.M. 💜

  2. It’d be cool if you brought someone on to talk about zero balancing, rolfing, reflexology, and osteopathy.😁Also, myofascial release, manual therapy, and lymphotherapy in another episode.

  3. “Migraines are the worst, but the easiest to treat.”

    Powerful. It proves that if you truly have the willpower to get better, you can. Change your habits, change your life.

    With love, Visual Venture ❤️


    “For every complex problem there is an answer that is clear, simple, and wrong.”

    “No one ever went broke underestimating the taste [or intelligence] of the American public.” HL Mencken

  5. At 29, 5 years of bad sleep and I can’t work nor walk properly, sleep is fundamentally important to brain health.

    It isn’t all reversible but I’m glad some was, now I sleep at 10pm and wake at 6am

  6. Pathophysiology of migraine. It’s complicated.


    “Migraine aura is defined as a focal neurologic disturbance manifest as visual, sensory, or motor symptoms. It is seen in about 30% of patients, and it is clearly neurally driven. The case for the aura being the human equivalent of the cortical spreading depression (CSD) of Leao, has been well made. In humans visual aura has been described as affecting the visual field, suggesting the visual cortex, and it starts at the center of the visual field, propagating to the periphery at a speed of 3 mm/min, and has been mapped in detail. This is very similar to spreading depression described in rabbits. Blood flow studies in patients have also shown that a focal hyperemia tends to precede the spreading oligemia, and again this is similar to what would be expected with spreading depression. After this passage of oligemia, the cerebrovascular response to hypercapnia in patients is blunted while autoregulation remains intact. Again this pattern is repeated with experimental spreading depression. An interesting recent study suggested that female mice are more susceptible generally to CSD than male mice, which would be consistent with the excess risk of migraine in females after menarche that is, still with them, on a population basis, into menopause and afterward. Human observations have rendered the arguments reasonably sound that human aura has as its equivalent in animals cortical spreading depression. An area of controversy surrounds whether aura in fact triggers the rest of the attack and is indeed painful. Based on the available experimental and clinical data, this investigator is not at all convinced that aura is painful, but this does not diminish its interest or the importance of understanding it. Indeed, therapeutic developments may shed even further light on these relationships.”

    Goadsby and Holland

  7. Altered connectivity and network disorder: Resting-state functional connectivity MRI — used in multiple studies of migraine; assesses cross talk between areas of the brain by measuring the correlation of low-frequency spontaneous fluctuations among remote brain areas; alterations in network connectivity have been demonstrated in multiple cortical and subcortical brain regions in studies that compared patients with migraine during the interictal phase to healthy controls with no history of migraine and in comparisons of scans performed during and outside of migraine attacks in patients with migraine; alterations have been identified in more than 20 networks, including multiple cortical regions, the thalamus, hypothalamus, brainstem, amygdala, and cerebellum; however, the specificity of these alterations to migraine is unclear; studies suggest widespread altered brain function in patients with migraine that could explain interictal cognitive, autonomic, and sensory symptoms.

    Cortical spreading depolarization: Supported by indirect evidence as the pathophysiologic mechanism of aura; consists of a wave of intense cortical neuronal activity associated with hyperemia followed by a prolonged period of suppression of neuronal activity associated with cortical oligemia; observed in the human brain after stroke or traumatic brain injury; however, no direct evidence exists that cortical spreading polarization occurs simultaneously with aura in humans; its role in triggering migraine attacks or as a direct cause of headache remains controversial.

    Silent migraine aura: This concept originated from imaging studies showing changes in cortical blood flow that resembled those caused by cortical spreading depolarization; a study that evaluated drawings of visual aura (made by one individual in real time over 18 years) suggests that aura originates in multiple sites of the visual cortex (although some areas have greater propensity to be the initiating focus); the mechanism underlying visual aura appears to propagate in a linear fashion along gyri or sulci, rather than spreading as a concentric wave (as previously depicted, based on animal models); the authors concluded that aura may propagate silently in the cortex without resulting in clinical manifestation.

    Trigeminal vascular pathway and migraine pain: Most cranial structures are innervated by trigeminal afferent nerves that, along with cervical afferents from the upper cervical dorsal root ganglia, synapse on second-order neurons in the dorsal horn of the trigeminal nucleus caudalis and the trigeminal cervical complex; from the trigeminal cervical complex, second-order neurons project to the thalamus and other key regions of the central nervous system that modulate sensory processing, after which sensory information is relayed by thalamocortical neurons to multiple cortical areas; several medullary, brainstem, and hypothalamic nuclei that send or receive projections have been implicated in trigeminal vascular sensory modulation.

    Pathway activation and generation of migraine attack: Some experts maintain that nociceptive activation of the peripheral trigeminal nociceptors is necessary for the perception of head pain and implicates occurrence of cortical spreading depolarization and peripheral sensitization of perivascular sensory terminals; other experts attribute migraine pain to abnormal central processing of normal sensory input from the peripheral trigeminal sensory system; although the controversy remains unresolved, most would agree that migraine is a disorder of the central nervous system with contribution from peripheral mechanisms; therapeutic trials have demonstrated the efficacy of treatments that cross the blood-brain barrier and of those that do not; therefore, it is likely that a combination of central and peripheral factors contributes to migraine.

  8. On July 4th 1993 I was putting the playpen in the trunk of the car, the spring on the trunk was broke and used a board to hold it up. The board shifted and the trunk lid fell on my head. I never sought medical treatment. I was sick with nausea and slept a lot that week. I seemed fine but experienced migraines for several years. Again, I never sought medical treatment. The migraines went away however, around 2014 I started having seizures in my sleep. The neurologists just want to throw meds at me but I want to know why. The MRI was negative and the EEG shows temporal lobe seizures and they want to diagnose me with adult onset Epilepsy.

  9. favorite guest! 👏 👏 👏

    I added all of Dr. Todd LePine’s videos to my playlist. I always learn so much from him. I really appreciate that he has no ego, and just sincerely wants to help people heal. 🙏✨💕

Leave a Reply

Your email address will not be published. Required fields are marked *