Lauren Elman, M.D., associate professor of neurology at the Hospital of the University of Pennsylvania and Penn Medicine, discusses her research with primary lateral sclerosis (PLS), a rare motor neuron disease often mistaken for ALS. #PrimaryLateralSclerosis #JohnsHopkins https://www.hopkinsmedicine.org/neurology_neurosurgery/clinical-trials/als-clinical-trials/
2:15 PLS History
6:48 Natural History of PLS
14:31 Clinical Care in PLS
15:37 What’s needed to conduct PLS clinical trials?
18:06 Neuropathology of PLS
27:23 Consensus Diagnostic Criteria
35:32 Neurobiology of PLS
38:19 Genetics of PLS
39:03 Are ALS and PLS part of a spectrum of disease?
40:22 Biomarkers in PLS
43:34 Neuroimaging in PLS
47:24 Measuring PLS Progression
54:16 Clinical Trial Targets — Symptomatic
55:31 Clinical Trial Targets — Disease Modifying