Sunday, December 5, 2021
Mitochondrial Health

Sirtuins reduce Insulin Resistance and Mitochondrial Dysfunction



Scientific Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432223/

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0:00 – Introduction
3:10 – Diabetes Background
8:30 – Mitochondria Background
13:33 – Mitochondria & Insulin Resistance
20:33 – Sirtuins
43:40 – Conclusions/Take Aways

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#sirtuins #diabetes #mitochondria

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15 thoughts on “Sirtuins reduce Insulin Resistance and Mitochondrial Dysfunction
  1. oh shit! you mentioned David Sinclair! He was on my list of questions I have for you sir!
    Awesome, looking forward to see you investigate his work.
    PS: BTW you said "we will be discussting the…" 😆

  2. While watching I googled "how to increase sirtuins' and "sirtuins and insulin resistance". Lol. Very interesting video. Heard about sirtuins before but never knew what they did. Thanks.

  3. UPDATE: YT deleted the article link. Sent link to you via request in show notes. Found an article on the Virta website by Phinney and Volek titled "Inflammation, Nutritional Ketosis, and Keto-Immune Modulation: New Insights Into How Virta Can Reverse Type 2 Diabetes". Talks about how a diet less than 30% of carb and protein (ketogenic) lowers mitochondrial ROS while a diet > 30% carb and protein( non-ketogenic) increases ROS.

  4. Superoxide is innately found in the mitochondria, so I should take this information as something the body creates on it's own? We make our own antioxidants or are there more functions for superoxide?

    Glycosylase is reading and fixing errors in genes, what are it's components and how do we help this system? If errors happen 1 out of 100 million times should we consider that cancers are a result of a poorly functioning Glycosylase system, perhaps the body is not receiving the correct nutrition an over abundance of poor nutrition that just adds more stress to the already poorly functioning system.

    How do these systems perform during fasting, during high energy intake, low energy intake over LONG periods of time and will different foods create different components of these systems, specifically Glycosylase?

    Sirtuins sound like messengers in a cell, is that their role in a nutshell?

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