Wednesday, August 10, 2022
Mitochondrial Health

A paradigm shift in aging research?

It has been known for some time that young blood plasma can confer beneficial effects on various organs in mice, although the mechanisms and implications remained unclear. A recent breakthrough experiment is attracting more attention to this area of research: rats treated with a blood plasma mixture known as E5 subsequently had their effective biological age measured by epigenetic clocks, involving 593 tissue samples. The result was a halving of the epigenetic ages of blood, heart, and liver tissue, and a lesser reduction (still statistically significant) in the epigenetic age of the hypothalamus. This has been heralded as the single most dramatic age-reversal experiment in mammals to date.

On Saturday 18th September, the lead designer of these experiments, Dr Harold Katcher, joined London Futurists to present his analysis of the findings, his own distinctive theories of aging, and his expectation for future research and applications. He also answered questions about his new book, “The Illusion of Knowledge: The paradigm shift in aging research that shows the way to human rejuvenation”, which is available at

The event was introduced and moderated by David Wood, Chair of London Futurists.

For more information about this event and the speaker, see

Also taking part in this event were Nicolas Chernavsky and Nina Torres Zanvettor of NTZ, the publishers of Dr Katcher’s book. For information about NTZ see

For more details of the experiments with E5, see


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9 thoughts on “A paradigm shift in aging research?
    “No longer will there be in it an infant who lives but a few days, Or an old man who does not live out his days; For the youth will die at the age of one hundred And the one who does not reach the age of one hundred Will be thought accursed. (ISAIAH 65:20, NASB1995)

  2. Outstanding video. Outstanding presentation especially the presentation at the start showing disease of later life circling old age.
    Harald is undoubtedly a genius and what he has discovered will change our world and others. Allowing us interstellar travel in one lifetime. A very long one!
    This discovery/invention almost completes the pillars of health. Hygiene, vaccination, antibiotics, medical procedures and lastly youth regeneration. This is the most astonishing thing I can imagine coming into reality.

  3. This is really exciting in the near term, assuming it pans out. Let's hope it succeeds and that the forms of damage that E5 is not able to overcome will not be neglected, but that their repair will continue to be researched and brought to the clinic.

  4. Lets see what happens. I'd love E5 to work, but if it fails i still wont be discouraged because reprogramming cells has become very promising according to many scientists anyways. So this is exciting times for biomedical science

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