In this episode, Dr. Mark Mattson discusses how stressing the body through exercise, fasting, and plant phytochemicals have beneficial effects on the brain and overall health.
Dr. Mark Mattson is an adjunct professor of neuroscience at the Johns Hopkins University School of Medicine and the former chief of the Neuroscience Research Laboratory at the National Institute on Aging. He is one of the most cited neuroscientists in the world, with more than 180,000 citations of his work noted in the scientific literature.
Dr. Mattson’s rigorous work has advanced scientific understanding of brain aging and identified fundamental aspects of age-related neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease. His most notable work has focused on how the brain responds to mild stressors, such as those associated with exercise and intermittent fasting.
You can access the show’s notes, timeline, and transcript here:
Listen to this interview as an Apple Podcast:
Dr. Mattson’s faculty bio page:
00:00:00 – Introduction
00:11:33 – Metabolic switch
00:16:14 – Different types of intermittent fasting
00:29:37 – Benefits from a ketogenic diet vs fasting
00:38:18 – Exercise and fasting
00:59:07 – Benefits of plant phytochemicals
01:25:18 – Safety considerations for fasting
01:34:43 – Fasting and women’s hormones
02:03:42 – Fasting mimetics
02:18:51 – Ketone esters