Speaker: Daniel Needleman, Harvard
Title: Cytoskeletal Energetics and Energy Metabolism
Abstract: Life is a nonequilibrium phenomenon. Metabolism provides a continuous flux of energy that dictates the form and function of many subcellular structures. These subcellular structures are active materials, composed of molecules which use chemical energy to perform mechanical work and locally violate detailed balance. One of the most dramatic examples of such a self-organizing structure is the spindle, the cytoskeletal based assembly which segregates chromosomes during cell division. Despite its central role, very little is known about the nonequilibrium thermodynamics of active subcellular matter, such as the spindle. In this talk, I will describe ongoing work from my lab aimed at understanding the flows of energy which drive the nonequilibrium behaviors of the cytoskeleton in vitro and in vivo.