ATP synthase harnesses the potential energy of the proton gradient to synthesize ATP. Subscribe to Nourishable at https://www.youtube.com/c/Nourishable
This video is part 4 of the Cell Metabolism module within a lecture series on the nutrition science of macronutrients.
Cell Metabolism Lecture playlist: https://youtube.com/playlist?list=PLK6oS2Cd-6PHrl1-OC3jiuiW5azktZv0_
Macronutrients Lecture playlist: https://youtube.com/playlist?list=PLK6oS2Cd-6PGI0ALaBRBb10s51Z0NEmvw
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Chapter 9 Wardlaw’s Perspectives in Nutrition, 2019 (Editors: Byrd-Bredbenner, Moe, Berning and Kelley, 11th edition)
ATP synthase is a large protein complex that enables protons to enter from the inner membrane space, fall down a slide that causes the complex to turn, and then spits out protons into the matrix. As ATP synthase spins, it brings ADP and a phosphate group in very close proximity, so close that they form a phosphate bond. The potential energy of the proton falling down its concentration gradient into the matrix is transferred into the phosphate bond of ATP.