Monday, November 28, 2022
Mitochondrial Health

David Sinclair: Is Epigenetic Noise The Reason We Age? Reverse Aging with Sweet Fruit

Is aging loss of digital or analog information? Is epigenetic noise the reason we age?
The Sinclair lab is driven by the belief that humanity can do better and that everyone has the right to the best medical care and maximum lifespan, no matter their gender, social status, or age. Work by our lab and others has shown that the pace of aging is not inexorable or predetermined, but rather can be slowed and even reversed by a variety of approaches. These include activating the body’s defenses against aging, deleting senescent cells, and reprogramming cells in vivo. In doing so, we can protect the body against and treat both rare and common diseases including mitochondrial diseases, type 2 diabetes, Alzheimer’s disease, cardiovascular disease, and cancer.
Reprogramming cells to be young again.

Visionary approach
Ageing affects the body in myriad ways — among them, adding, removing or altering chemical groups such as methyls on DNA. These ‘epigenetic’ changes accumulate as a person ages, and some researchers have proposed tracking the changes as a way of calibrating a molecular clock to measure biological age, an assessment that takes into account biological wear-and-tear and can differ from chronological age.

That has raised the possibility that epigenetic changes contribute to the effects of ageing. “We set out with a question: if epigenetic changes are a driver of ageing, can you reset the epigenome?” says David Sinclair, a geneticist at Harvard Medical School in Boston, Massachusetts, and a co-author of the Nature study. “Can you reverse the clock?”

What does DNA methylation have to do with epigenetics?
DNA methylation is an epigenetic mechanism used by cells to control gene expression. A number of mechanisms exist to control gene expression in eukaryotes, but DNA methylation is a commonly used epigenetic signaling tool that can fix genes in the “off” position.

Epigenetics is the study of how your behaviors and environment can cause changes that affect the way your genes work. Unlike genetic changes, epigenetic changes are reversible and do not change your DNA sequence, but they can change how your body reads a DNA sequence

What are 3 factors that affect epigenetics?
Several lifestyle factors have been identified that might modify epigenetic patterns, such as diet, obesity, physical activity, tobacco smoking, alcohol consumption, environmental pollutants, psychological stress, and working on night shifts.

Can radiation affect you years later?
Radiation to the brain can also have side effects that show up later – usually from 6 months to many years after treatment ends. These delayed effects can include serious problems such as memory loss, stroke-like symptoms, and poor brain function.

Do X-rays cause aging?
This type of radiation causes premature aging, cataracts, and skin cancer. Ionizing radiation comes in several different forms of varying intensity (alpha, beta, gamma, x-ray and neutron), and it is ionizing radiation that can impair normal cell function and/or kills cells by interfering with the cell’s DNA.
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CREDITS: David Sinclair

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3 thoughts on “David Sinclair: Is Epigenetic Noise The Reason We Age? Reverse Aging with Sweet Fruit
  1. David,

    I just started reading your book, Lifespan, yesterday at the request of a friend. Even though I’ve studied science since 1960, I’ve stopped reading any books by medical people, doctors or researchers, because their scientific abilities, in general, are so poor.

    I have to admit that for the first 147 pages, I was impressed even though you said a few things that were totally wrong. I’m assuming you are a good researcher, but then page 148 happened.

    On that page you stated that you believed in the beneficial effects of vaccination! This is shocking to me because you seem to have no clue that vaccination, next to current AMA cancer therapies, are the worst thing that the medical system has ever done to humanity. Vaccination has damaged BILLIONS of people and has dramatically shortened the lives of MILLIONS of people, never really even helping one person.

    Now, you may ask who the hell am I, not being a medical researcher, so I’ll tell you. I fell in love with science in November of 1960, when I was in the second grade. Since then, I’ve read over 3,500 science books, performed hundreds of scientific experiments, solved tens of thousands of scientific, mathematical and engineering problems.

    What woke me up about vaccination was the fact that my children were both damaged by vaccines in the 1990s. Because of that I did some research on the topic and was shocked when I read a 1898 scientific paper by a British scientist, Alfred Russel Wallace, that was called “Vaccination a Delusion: It’s Penal Enforcement a Crime.” You can easily find the original paper on the Internet, which you should do immediately. If you do, then you will find that Jenner’s vaccine was one of the three major CAUSES of smallpox, and NEVER reduced it.

    I hope you can learn about this.


    Victor Connor

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