Friday, July 1, 2022
Mitochondrial Health

Matt Kaeberlein | Aging Interventions – Rapamycin, mTOR, CR, Sirtuins, NAD+ & Dog Aging Project

Live Longer World Podcast #5

Dr. Matt Kaeberlein is a Professor of Pathology, Adjunct Professor of Genome Sciences, and Adjunct Professor of Oral Health Sciences at the University of Washington. His research interests are focused on basic mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life.

Matt has been around the field of aging for a long time and knows more about the work in the aging field than perhaps anyone else. This was a comprehensive conversation where we spoke about how Matt thinks of aging from a functional perspective, caloric restriction and aging, whether NAD+ precursors are effective in slowing aging, the role of sirtuins.

We discuss quite a bit on rapamycin and how it’s shown to be effective in improving the health of mice. Matt is very excited about the potential benefits of Rapamycin in reversing aging and he got me excited too. Matt is also working on the Dog Aging project and in trying to understand aging in dogs.

Finally, we end the conversation by talking a bit on what good scientific practices should look like. Matt approaches his work with an unbiased lens and that’s very respectable.

Matt has a brilliant mind! I had such a blast talking to Matt and I hope you enjoy the conversation as much as I did!

Timestamps in the comments below.






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Dog Aging Project:

#longevity #rapamycin #dogagingproject #sirtuins #nad #antiaging


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2 thoughts on “Matt Kaeberlein | Aging Interventions – Rapamycin, mTOR, CR, Sirtuins, NAD+ & Dog Aging Project
  1. 0:00 Welcome to Live Longer World

    1:00 Matt Kaeberlein Intro
    2:28 Aging as Functional Decline & the Biology of Aging
    7:40 Will there ever be one definition of aging?
    9:32 Caloric restriction as Aging intervention – history & its effects depend on genetics
    14:54 Do the Caloric restriction studies look at composition of diet?
    17:20 Prolonged Fasting could improve lifespan & healthspan (perhaps because of Caloric Restriction)
    20:16 What is the data on Caloric Restriction for humans? Does it benefit healthy humans?
    22:00 CALERIE study (human study on caloric restriction)
    24:32 Sirtuins & Longevity
    28:50 Are NAD precursors activating sirtuins to boost longevity?
    31:34 mTOR from an evolutionary perspective, mTOR1 & mTOR2
    37:35 Rapamycin as gold standard for longevity
    39:18 Would Rapamycin work in all genetic backgrounds?
    40:35 What age should you take Rapamycin?
    44:10 Do low protein diets inhibit mTOR?
    48:54 Do we know much about mTOR2? (Rethinking that inhibition of mTOR2 is "bad")
    53:32 Dogma around mTOR2 inhibition being "bad"
    54:54 Dog Aging Project
    59:00 Size being the biggest determinant of aging in dogs
    59:50 Rapamycin dosage & clinical study time for the Dog Aging Project
    1:02:35 Testing Rapamycin in diverse genetic pool in dogs
    1:04:09 Feeding frequency in dogs & Aging
    1:08:57 What Rapamycin studies does Matt want to see?
    1:11:31 Science is not immune to marketing games
    1:12:25 Inflammaging (Change in Immune System with Aging)
    1:17:43 Rapamycin & COVID-19
    1:21:45 What is good & unbiased science?
    1:28:40 How can we accelerate testing of interventions that are really promising?
    1:32:19 Support Live Longer World

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