Saturday, August 13, 2022
Mitochondrial Health

CMPK2 Restricts the Replication of Multiple Flaviviruses



Presented By: Maudry Laurent-Rolle, MD/PhD

Speaker Biography: Dr. Maudry Laurent-Rolle received her B.S. from Long Island University, Brooklyn Campus in Biology. She then obtained her MD and PhD from the Icahn School of Medicine at Mount Sinai. Her dissertation research was funded by an NIH pre-doctoral fellowship where she studied the molecular mechanisms by which flaviviruses inhibit host innate immune responses. Dr. Laurent-Rolle went on to do her residency training in Internal Medicine at Albert Einstein/Montefiore Medical Center. Subsequently, she joined the Infectious Diseases Fellowship program at Yale New Haven Hospital where she remained after her training as an Assistant Professor in the Department of Internal Medicine, Section of Infectious Diseases. Currently, Dr. Laurent-Rolle’s research focus is on understanding how host responses to viruses prevent diseases and on vaccine design and development of antivirals.

Webinar: CMPK2 Restricts the Replication of Multiple Flaviviruses

Webinar Abstract: Flaviviruses are pathogens of global public health concern. They include dengue virus (DENV), West Nile virus (WNV), and zika virus (ZIKV). There are no approved US Food and Drug Administration antivirals for any flavivirus. The type I interferon (IFN-I) system is the first line of defense against viral infection. Activation of IFN-I signaling leads to the induction of hundreds of IFN stimulated genes (ISGs), the products of many serve to limit viral replication. One of these ISGs, Cytidine monophosphate kinase (CMPK2), is a potential anti-flavivirus drug target. CMPK2 is an interferon inducible enzyme with a mitochondrial localization sequence (MLS) at its N-terminus that localizes it to the mitochondria where it plays an important role in maintenance of cellular nucleic acid synthesis. The N-terminal domain (NTD) of human CMPK2 contains no known sequence homology to any other species and the C-terminal domain (CTD) is highly conserved across species and is responsible for its kinase activity.

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