Saturday, August 13, 2022
Mitochondrial Health

DAVID SINCLAIR “One Therapy To Reverse All Hallmarks Of Aging” | Dr David Sinclair Interview Clips



An increasing number of studies suggest the presence of a “metabolic clock” that controls aging. This clock involves the accumulation of metabolic alterations and a decline in metabolic homeostasis and biological fitness. There are nine cellular hallmarks of aging: telomere attrition, genomic instability, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, loss of proteostasis, deregulated nutrient sensing, epigenetic alterations, and altered intercellular communication. Metabolic alterations have been implicated in each of these processes.

https://www.cell.com/fulltext/S0092-8674(13)00645-4
https://www.cell.com/cell/pdf/S0092-8674(16)30981-3.pdf

David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.

Dr David Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political and benefits of a world in which billions of people can live much longer and much healthier lives.

Dr David Sinclair is the co-founder of several biotechnology companies (Life Biosciences, Sirtris, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others.
He is also co-founder and co-chief editor of the journal Aging. He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time’s Top 50 in healthcare in 2018.
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DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes.

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20 thoughts on “DAVID SINCLAIR “One Therapy To Reverse All Hallmarks Of Aging” | Dr David Sinclair Interview Clips
  1. Like gene therapy introducing those anti-aging genes can reverse aging as well as age related diseases!
    I am approaching patient with metabolic pathways correction method cuz those are the medications which is available in market easily 🙏😊😅

  2. On a side note has anyone else notice from David Sinclair's earlier videos done years ago, that his hairline was receding back then? And if so might he be using topical NMN on his scalp?

  3. Good information. Ultimately I think we'll see a wide variety of therapeutic approaches to mitigating aging, from drugs like rapamycin, to blood treatments similar to what is being achieved by parabiosis, and then potentially cellular reprogramming in the long term

  4. It's always a question of cause and effect. The limitation of the Horvath epigenetic clock is that there is no theory of why the different chemical markers are changing with age, and can be used to predict lifespan. If the goal is to predict someone's lifespan, fine, but otherwise they appear to be measurements of effects, the causes leading to which are unknown, and of limited usefulness for that reason.

    I was glad to hear telomerase activation mentioned. This is one of my own personal immortality strategies. (lol) A timid reader investigating this subject might be turned away by all of the literature on cancer and how cancer cells activate telomerase and become immortal. This doesn't mean, though, that the reverse would be true. If something else activates telomerase, that might not even help existing cancer cells, that can activate it on their own.

    Obviously, the remedy has to be available in the form of an OTC dietary supplement. Luckily, the best known one is. An ethanol extract of centella asiatica, or gotu kola, has been shown to dramatically activate telomerase in vitro, in human blood cells, and in kidney cells, by different researchers. It's an ancient traditional medicine, in China, India and Indonesia, with no known risks of cancer, or much toxicity. Although there are some legends, there is no real data showing that this effect leads to longer lifespans, in people who eat gotu kola as a regular part of their diet. Still, it seems like the risk benefit/ratio is OK – in fact, I'm going to make a gotu kola tea right now.

  5. I don't understand though not to be cruel or anything like that but if he knows or is learning how to reverse aging why does he look like he's hitting 50 if he's not already 50 something I don't get it?
    So If you reverse aging on the inside won't it show on the outside somehow,
    or not?? 🙄

  6. Dr. Sinclair talks a lot about aging and rejuvenation. Let me ask Dr. Sinclair to explain the nature of aging: where does it begin in the human body, how does it develop, what dies first in the human body? Or will you delete my question again? – FB/ Physiology of Aging and Rejuvenating Physiotherapy

  7. All these hallmarks are connected to Teleomere shortening. Now I see what they are doing. Trying to make money from each effect of telomere shortening since they cant cure it yet. Unfortunately they are perplexed by each of these effects of telomere shortening as well even NAD+ had been found to have complications. Reverse telomere shortening and you cure aging. Figure it out.

  8. Repair the cell membranes using NT Factor Energy Lipids and CDP-Choline. Then start taking MitoQ, L-Carnitine, D-Ribose, and Magnesium to restore mitochondrial function. There are some others as well like Niacin/TMG to restore NAD+ levels. It all boils down to cell membrane function and health of the mitochondria and NO body or cellular inflammation. Yes, I'm a health professional and have trained in disease prevention anti-aging for over 20 years.

  9. What causes ageing is not looking after yourself and smoking , Iam in my mid fifties and most people think I am in my thirties,and they don’t believe me when I tell them my real age ,so I have stopped and say Iam younger,I drink alcohol at the weekends,I eat carrots/spinach/broccoli/chicken and fish/salmon/cod /eggs and I love fruit bananas/apples /kiwi fruit/pears/pineapple /cranberry /grapes on daily basis and vitamin drinks I also eat organic and use various spices in with my meals like turmeric and cinnamon,I work out 2 times a week and I have a six pack, Iam not married,married couples tend to let themselves go or tend to sacarafice eating healthy so their children don’t go without.

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