Presented By: Mark McNiven, PhD
Speaker Biography: Mark A. McNiven, Ph.D., is a consultant in the Division of Gastroenterology and Hepatology, Department of Internal Medicine, with a joint appointment in the Department of Biochemistry and Molecular Biology at Mayo Clinic in Rochester, Minnesota. Dr. McNiven is director of the Gastrointestinal Cancer Program at Mayo Clinic Cancer Center and director of the Mayo Center for Biomedical Discovery. He joined the staff of Mayo Clinic in 1989 and chaired the Department of Biochemistry and Molecular Biology from 2000 to 2011. He holds the academic rank of Professor of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, and is recognized with the distinction of the George M. Eisenberg Professorship.
Webinar: Keynote Presentation: Membrane-Cytoskeletal Dynamics in Disease
Webinar Abstract: Cells of the liver and pancreas are highly polarized and well differentiated, contributing to food digestion through the secretion of lipid emulsifying bile, and proteolytic juice into the gut. Both have sophisticated cytoskeletal membrane trafficking machineries that aid in this secretory process while ensuring the maintenance of apical and basolateral membrane domains. Unfortunately, these organs can become steatotic (fatty), leading to a variety of different diseases. Further, as the liver is a central blood filtering organ, it also can become infected by a substantial variety of different pathogens. Both steatosis and chronic infections are known to lead to cancers of the liver and pancreas that are among the most lethal of all cancers with exceptionally poor prognoses.
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