Saturday, August 13, 2022
Mitochondrial Health

Ep. 76: Why Caloric Restriction Is NOT Responsible For Lifespan Extension (Hormesis Part 2)



Show Notes: https://jayfeldmanwellness.com/ep-76-why-caloric-restriction-is-not-responsible-for-lifespan-extension-hormesis-part-2/
Free Energy Balance Mini-Course: https://jayfeldmanwellness.com/energy
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Jay’s Website: https://jayfeldmanwellness.com/
Mike’s Website: https://mikefavenp.com/

In this episode we discuss:
-How the largest body of evidence cited in favor of hormesis actually doesn’t support it at all
-Why caloric restriction is NOT responsible for slowing aging and extending lifespan (and what is actually responsible)
-The many factors that confound the calorie restriction research (including differences between organisms, poor research design, amino acid restriction, PUFA, endotoxin, and more)

0:00 – intro
3:36 – the physiology of hormesis and the general support for hormesis
12:54 – outlining the problems with hormesis
18:51 – how differences between organisms confound the caloric restriction research
37:34 – the problem with using proxy markers to evaluate health effects and the importance of context
48:20 – how differences between organisms confound the caloric restriction research (cont.)
51:58 – how hydration status and macronutrient ratios confound the caloric restriction research
55:57 – how the myopic hormetic view leads to the ignorance of many confounding variables
1:02:00 – how the restriction of particular amino acids, ad libitum feeding, and a refined diet confound the caloric restriction research
1:11:58 – how PUFA confounds the caloric restriction research
1:30:09 – how endotoxin and gut health confounds the caloric restriction research

​​To see the studies and articles referenced throughout this episode, check out the show notes at https://jayfeldmanwellness.com/ep-76-why-caloric-restriction-is-not-responsible-for-lifespan-extension-hormesis-part-2/

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5 thoughts on “Ep. 76: Why Caloric Restriction Is NOT Responsible For Lifespan Extension (Hormesis Part 2)
  1. Interesting perspectives on lifespan regulation ! Currently doing a PhD in epigenetics and longevity using bumblebees as model organisms. Way more extrapolable results than C. elegans IMO (and more fun to work with 🙂 )

    – Cheers from Belgium

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