Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme that is involved in many essential biological processes in live cells, such as adenosine triphosphate (ATP) production, DNA repair, epigenetic modulation of gene expression, intracellular calcium signaling, and immune regulatory functions. As we age, immune system activation and increased levels of DNA damage utilize much of the body’s NAD+. As NAD+ is a common substrate between DNA repair proteins PARPs and as well as enzymes that can influence DNA repair capacity such as SIRT1 and SIRT6, there is a competition between these activities. High PARP activity can drain cellular NAD+ reserves, and SIRT1 activity is reduced, causing an organism’s functional decline.
David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.
Dr David Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political and benefits of a world in which billions of people can live much longer and much healthier lives.
Dr David Sinclair is the co-founder of several biotechnology companies (Life Biosciences, Sirtris, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others.
He is also co-founder and co-chief editor of the journal Aging. He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time’s Top 50 in healthcare in 2018.
DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes.
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