David Andrew Sinclair, PhD is an Australian biologist and professor of genetics. He is also a co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, and is known for his research on aging with a focus on epigenetics.
0:29:37 Podcast begins with David Sinclair
0:30:45 Is when we eat more important than what we eat?
0:32:55 What is the connection between time restrictive eating and longevity?
0:38:04 What causes us to age?
0:39:56 Epigenetic change.
0:47:13 What causes DNA breaks?
0:49:38 What plant foods create DNA breaks?
0:51:23 PARP enzymes
0:54:56 Where does NAD come from? How do we make it? What enzymes use it?
0:59:00 NAD recycling pathway.
1:18:24 What are the other longevity genes? (AMP kinase and mTOR) How are they connected to sirtuins?
1:26:00 Does being in a ketogenic state increase NAD?
1:34:40 Xenohormesis and plant molecules.
1:40:00 Resveratrol trials.
1:51:35 David’s thoughts on animal protein.
1:58:13 Meat consumption in relation to the environment and regenerative agriculture.
2:05:38 Where to find David Sinclair.
Heart & Soil: www.heartandsoil.co
Animal-Based Gathering: https://www.animalbasedgathering.com/