Tuesday, January 31, 2023
Mitochondrial Health

Autophagy: How does it stay Healthy? [Study 25]



Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs25%5D-metabolic-regulation-of-mitochondrial-dynamics

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0:00 – Introduction
3:55 – Understanding Autophagy
6:00 – Autophagy Regulation
6:54 – Triggering Selective Autophagy
15:10 – How the Cell Maintains Healthy Autophagy
17:03 – Other mechanisms controlling PINK
19:09 – Conclusions/Take Aways

#autophagy #cellbiology #health

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19 thoughts on “Autophagy: How does it stay Healthy? [Study 25]
  1. Was thinking to myself: will he talk about ubiquitine, the molecule that came into the limelight in the late nineties & then suddenly disappeared into oblivion? Glad u brought it up in the exposé. Why not devote a vid just to the ubiquitous ubiquitine?

  2. ESSENTIALLY , WHEN THE MITOCHONDRIA CAN NOT SEPARATE THE PROTONS AND ELECTRONS, ONE OF THE MAIN FUNCTIONS OF THE MITOCHONDRIA, THE POLARITY CHANGES, MAKING THE DYSFUNCTIONAL MITOCHONDRIA A TARGET ?

  3. Very interesting. 2 things. 1. Probably very complicated but HOW do they learn how these processes occur at this very granular level? Cell staining, isotopes, etc.? 2. Tommy Wood, MD, PhD said on a recent Diet Doctor podcast that 30 minutes of aerobic exercise at 70% VO2 max stimulates as much autophagy as 3 days of water fasting. So, what about exercise leads to that increased autophagy?

  4. I'm going to risk an annoying, unrelated question. You said you take Nordic Naturals fish oil. Do you trust Amazon and Ebay not to be counterfeit or rancid? ….or do you order straight from the company? Sorry to pester you but hey, comments they say count on the Youtube algorithms.

  5. I have seen from several sources that green tea, earl grey tea, and licorice can all aid in autophagy. They seem like old wives' tales after watching your explanation. Is there any way these substances could effect the process?

  6. Nic

    Thanks alot for your great content keep it up bro

    I have lots of questions but ill add few to make your life easier

    1st of all you did not mention is pink1 is available all the time the body or it is formed by the fasting cause logically if its available normally in the body then why this process don't happen while person not fasting ?

    Second question dose the autophagy happen to each cell of the body ? Mainly this quiestions cause I'm trying to find out if it might heal MPN disease of someone means the world to me she have MNP PV or ET with jack2 mutation

    If you can help me with some information about autophagy when it recycling the cell dose the new cell have the potential to correct mutation cause for sure not all the cells has the mutation dose autophagy has the ability to catch the mutation error ?

    Last question how long dose it take for the whole process to take a place until the cell is recycled and new healthy cell occurs and the pink1 concentration is it even in the whole body ?

    Hope I'm not asking too much

  7. Cells don't have brains? You've ruined my day.😐 (I think I've gone out with several "cells".)
    I wish you were my professor for cell biology. I had to resort to writing bawdy jokes in the margins of my tests to get through the 2 courses. I got an A and A- , but I think it was because the professor liked my jokes.

  8. Have you seen any of the research on how viral infection can trigger long term neurological inflammation and disregulation of mitochondrial function? Some suggest it is a trigger of MS/chronic fatigue. There is also enquiries into whether this explains long covid. All interesting future 'learn your body – physionics' topics?

  9. Autophagy (or rather, increasing it deliberately with longer intermittent fasts) is often talked about as being a positive thing for health. Is it always beneficial, and is this effect overstated? Would a healthy person not do this 'enough' anyway?

  10. So, would be the case that, for every type of proteins with action on the cell metabolism, would happen to have other vigilante proteins acting in parallel to check if it's still useful or should be directed to authophagy?

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