Wednesday, February 8, 2023
Mitochondrial Health

Urolithin A & Its Health Benefits | Dr Anurag Singh Interview Series Ep 1

In this video Dr. Singh introduces Urolithin A. We talk about the benefits of the molecule and its mechanisms of action.

Dr. Anurag Singh is the Chief Medical Officer of Amazentis a Swiss life science company focused on discovering and developing next generation natural compounds which target improvement in mitochondrial health. Dr Singh has led clinical development of Urolithin A, a natural mitophagy activator at Amazentis where he has spent 7 years in research and clinical trials of the molecule.

Amazentis website
Mitopure Website

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12 thoughts on “Urolithin A & Its Health Benefits | Dr Anurag Singh Interview Series Ep 1
  1. Thanks Richard. On your question about fasting and exercise impact on mitophagy – I just looked up half-life of mitochondria and it seems to be in the range of about 10 to 30 days depending on organ. So it seems that doing a deeper fast (something like FMD), along with exercise, one or two days every 2 ro 4 weeks, might help boost mitophagy as well as other forms of autophagy.

  2. Their product is really expensive. Richard as part of your future interview, can you add the question if they are actively trying to lower the cost allow non-millionairs also benefit.

  3. Hi Richard – will you try this supplement? Surprisingly only recently after 10+ yrs of study only now saying conducting a human study on endurance benefits. Seems could of done relatively much earlier a small 20 or 30 study with placebo control using healthy or even recreational runners to give approximate endurance benefits. Maybe did many in there lab but not published results and only wanting this bigger study based on smaller studies. Do you when to publish this human endurance study maybe based on any other communication you had with company. Thank you

  4. Hi Richard – looked at company site for the urolithon compound and most recent study found no statistical difference for endurance with urolithon vs placebo group at the 4 month endpoint. Not good news for this expensive compound.

    This double-blind, placebo-controlled trial in adults 65 to 90 years old (n=66) was conducted at the University of Washington School of Medicine with the professor of radiology David Marcinek as principal investigator. Participants were randomized to receive daily supplementation with 1000 mg Mitopure or placebo for 4 months. Muscle fatigue tests and plasma biomarkers were assessed at baseline, 2 months, and 4 months. Six-minute walk distance and maximal ATP production were also assessed at baseline and 4 months.

    Two measures of skeletal muscle endurance were improved in the supplemented group compared to the placebo group. Endurance was measured with isometric exercises involving the hand (first dorsal interosseous, between thumb and forefinger) and leg (tibialis anterior, alongside the shinbone.) After two months the number of muscle contractions until fatigue increased from baseline by ~17% (p=0.05 compared to placebo) for the leg muscle and 26% (p<0.01 compared to placebo) for the hand muscle for the group receiving Mitopure compared to 2% and 3% increase for placebo. Improvements vs baseline continued to be clinically meaningful at 4 months of intervention, but investigators found no statistical difference between the supplemented group and placebo at this time point. Measures of whole-body physical performance such as the distance covered during a six-minute walk also improved by ~15% vs baseline in the supplemented group as compared to ~10% in placebo- after four months. However, researchers saw no statistically significant effect of the supplement compared with the placebo.

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